Title:
A transportation regulation factor in a core, and its use
Document Type and Number:
Japanese Patent JP6006794
Kind Code:
B2
Abstract:
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by formula I:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
More Like This:
| WO/1995/002600 | ANTIALLERGIC IMIDAZOAZEPINES |
| JP2007503450 | Substituted 2,3-dihydro-1H-isoindru-1-one derivative and usage |
| JP3008195 | [Title of Invention] Anti-inflammatory composition |
Inventors:
Sandanayaka, Vincent, Pea.
Shacham, Sharon
Kauffman, Michael
Schecter, Sharon
Macquarie, Girara
Landesmann, Joseph
Senna Pedis, William
Saint-Martin, Jean-Richard
Shacham, Sharon
Kauffman, Michael
Schecter, Sharon
Macquarie, Girara
Landesmann, Joseph
Senna Pedis, William
Saint-Martin, Jean-Richard
Application Number:
JP2014523015A
Publication Date:
October 12, 2016
Filing Date:
July 26, 2012
Export Citation:
Assignee:
Kario Farm Therapeutics, Inc.
International Classes:
C07D401/06; A61K31/4196; A61K31/422; A61K31/435; A61K31/4439; A61K31/454; A61K31/497; A61K31/506; A61P13/12; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D413/12; C07D487/10
Domestic Patent References:
| JP10502970A | ||||
| JP2009203238A | ||||
| JP2010513342A | ||||
| JP4211089A | ||||
| JP11513382A | ||||
| JP2003524010A | ||||
| JP2010513341A | ||||
| JP2009536615A | ||||
| JP2005255683A | ||||
| JP11263764A | ||||
| JP7118237A | ||||
| JP62103065A | ||||
| JP58041875A | ||||
| JP2009544696A |
Foreign References:
| US20030018025 | ||||
| WO1997037996A1 | ||||
| WO1999050264A1 | ||||
| WO1998025893A1 | ||||
| WO2006016637A1 | ||||
| WO2005115990A1 | ||||
| WO2004076418A1 | ||||
| WO2004043951A1 | ||||
| WO2004043925A1 | ||||
| WO2008029825A1 |
Other References:
A. Yu. Karyagin,Reagents for addressed modification of biopolymers,Russian Chemical Bulletin,2000年,Vol.49,Issue3,PP.540-545
REGISTRY(STN)[online],2008年 1月23日,CAS登録番号 1000508-38-2
Tine Van Neck et al.,Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure?activity relationship and mechanism of action,Bioorganic & Medicinal Chemistry,2008年,Vol.16,PP.9487-9497
長瀬 博,最新 創薬化学 上巻,株式会社 テクノミック,1998年,P253
Cesarino Balsamini et al.,(E)-3-(2-(N-Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site Antagonists,Journal of Medicinal Chemistry,1998年,Vol.41,PP.808-820
REGISTRY(STN)[online],2008年 1月23日,CAS登録番号 1000508-38-2
Tine Van Neck et al.,Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure?activity relationship and mechanism of action,Bioorganic & Medicinal Chemistry,2008年,Vol.16,PP.9487-9497
長瀬 博,最新 創薬化学 上巻,株式会社 テクノミック,1998年,P253
Cesarino Balsamini et al.,(E)-3-(2-(N-Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site Antagonists,Journal of Medicinal Chemistry,1998年,Vol.41,PP.808-820
Attorney, Agent or Firm:
Yoshinori Hosoda