Title:
α、β不飽和アミド化合物
Document Type and Number:
Japanese Patent JP6983661
Kind Code:
B2
Abstract:
The present invention provides an ±,²-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I):
[wherein, "A" represents optionally substituted heterocyclic diyl,
R 1 represents hydrogen atom or optionally substituted lower alkyl,
R 2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group,
X represents -O-, -S-, -SO 2 -, -NR X1 - (wherein, R X1 represents hydrogen atom or lower alkyl), -CHR X2 - (wherein, R X2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and
n1 and n2 are the same or different, and each represents 0 or 1].
Inventors:
Tomohiro Dangami
Katsuaki Fujiwara
Toshiyuki Nishikawa
Nakajima Yudai
Otsubo Shin
Seiya Minoru Hiroshi
Katsuaki Fujiwara
Toshiyuki Nishikawa
Nakajima Yudai
Otsubo Shin
Seiya Minoru Hiroshi
Application Number:
JP2017558282A
Publication Date:
December 17, 2021
Filing Date:
December 22, 2016
Export Citation:
Assignee:
Kyowa Kirin Co., Ltd.
International Classes:
C07D215/38; A61K31/47; A61K31/4709; A61K31/497; A61K31/506; A61P1/16; A61P11/00; A61P15/00; A61P35/00; C07D215/12; C07D215/14; C07D215/20; C07D215/227; C07D215/233; C07D215/26; C07D215/36; C07D215/40; C07D401/12; C07D405/12
Domestic Patent References:
| JP2012524123A | ||||
| JP2013502424A | ||||
| JP2018502853A |
Foreign References:
| WO2015025197A1 | ||||
| US6002008 | ||||
| WO2012167600A1 | ||||
| US20150057312 |
Attorney, Agent or Firm:
Yukitaka Nakamura
Manabu Miyajima
Mari Asano
Hiroshi Sorimachi
Suzuki Keiyasu
Manabu Miyajima
Mari Asano
Hiroshi Sorimachi
Suzuki Keiyasu
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