Title:
1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/101265
Kind Code:
A1
Abstract:
Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.
Inventors:
LIU HONG (CN)
WU BEILI (CN)
ZHENG YONGTANG (CN)
XIE XIN (CN)
JIANG HUALIANG (CN)
PENG PANFENG (CN)
LUO RONGHUA (CN)
LI JING (CN)
LI JIAN (CN)
ZHU YA (CN)
CHEN YING (CN)
ZHANG HAONAN (CN)
YANG LIUMENG (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
WU BEILI (CN)
ZHENG YONGTANG (CN)
XIE XIN (CN)
JIANG HUALIANG (CN)
PENG PANFENG (CN)
LUO RONGHUA (CN)
LI JING (CN)
LI JIAN (CN)
ZHU YA (CN)
CHEN YING (CN)
ZHANG HAONAN (CN)
YANG LIUMENG (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2014/095421
Publication Date:
July 09, 2015
Filing Date:
December 29, 2014
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
International Classes:
A61K31/454; C07D409/14; A61K31/4545; A61K31/46; A61P31/18; C07D401/14; C07D451/04; C07D519/00
Domestic Patent References:
| WO2012177660A2 | 2012-12-27 |
Foreign References:
| US6511994B2 | 2003-01-28 |
Other References:
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3091013A4
See also references of EP 3091013A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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