Title:
1,3-BENZODIOXOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/141616
Kind Code:
A1
Abstract:
The present invention provides a compound having a specific chemical structure and having an exceptional inhibitory action on EZH1 and/or EZH2 activity, or a pharmaceutically acceptable salt thereof. A compound having a 1,3-benzodioxole structure represented by general formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing such a compound. (R1, R2, R3, R4, R5, R6, and V in formula (I) are each as defined in the specification.).
Inventors:
KANNO OSAMU (JP)
WATANABE JUN (JP)
HORIUCHI TAKAO (JP)
NAKAO AKIRA (JP)
SUZUKI KEISUKE (JP)
YAMASAKI TOMONORI (JP)
ADACHI NOBUAKI (JP)
HONMA DAISUKE (JP)
HAMADA YOSHITO (JP)
WATANABE JUN (JP)
HORIUCHI TAKAO (JP)
NAKAO AKIRA (JP)
SUZUKI KEISUKE (JP)
YAMASAKI TOMONORI (JP)
ADACHI NOBUAKI (JP)
HONMA DAISUKE (JP)
HAMADA YOSHITO (JP)
Application Number:
PCT/JP2015/057652
Publication Date:
September 24, 2015
Filing Date:
March 16, 2015
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K31/443; C07D405/12; A61K31/4433; A61K31/4439; A61K31/4545; A61K31/496; A61K31/5377; A61P35/00; A61P35/02; A61P43/00; C07D405/14; C07D417/14
Domestic Patent References:
| WO2014077784A1 | 2014-05-22 | |||
| WO2014055634A1 | 2014-04-10 | |||
| WO2009006577A2 | 2009-01-08 | |||
| WO2013067296A1 | 2013-05-10 | |||
| WO2013067302A1 | 2013-05-10 |
Other References:
KONZE, KYLE D. ET AL.: "An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1", ACS CHEMICAL BIOLOGY, vol. 8, no. 6, 21 June 2013 (2013-06-21), pages 1324 - 1334, XP055106961
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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