1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS

WIPO Patent Application WO2005097762

A3

The present invention is directed to 1, 3, 4-oxadiazolones, compounds of formula (I) and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula (I), in which radicals are as defined herein. The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization.

MCGARRY DANIEL G (US)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
WENDLER WOLFGANG (DE)
BERNARDELLI PATRICK (FR)

PCT/US2005/010854

December 15, 2005

March 30, 2005

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AVENTIS PHARMA INC (US)
MCGARRY DANIEL G (US)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
WENDLER WOLFGANG (DE)
BERNARDELLI PATRICK (FR)

A61K31/4245; C07D413/12; C07D417/12; (IPC1-7): C07D417/12; C07D413/12; A61K31/4245; A61P3/10; A61P3/06

WO2000078313A1	2000-12-28
WO2001000603A1	2001-01-04
WO2001017994A1	2001-03-15

S. S. KULKARNI ET AL.: "Three-Dimensional Quantitative Structure Activity Relationship (3-D-QSAR) of Antihyperglycemic Agents", BIOORG. MED. CHEM., vol. 7, 1999, pages 1475 - 1485, XP002345584
B. R. HENKE ET AL.: "N-(2-Benzoylphenyl)-L-tyrosine PPAR.gamma. Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents", J. MED. CHEM., vol. 41, no. 25, 11 November 1998 (1998-11-11), pages 5020 - 5036, XP000864731

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