Title:
1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2021/172887
Kind Code:
A1
Abstract:
The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.
Inventors:
LEE CHANG KON (KR)
KO MOO SUNG (KR)
YUN SEOK HYOUN (KR)
LEE SEO YOUNG (KR)
KIM HYUNJIN MICHAEL (KR)
KO MOO SUNG (KR)
YUN SEOK HYOUN (KR)
LEE SEO YOUNG (KR)
KIM HYUNJIN MICHAEL (KR)
Application Number:
PCT/KR2021/002364
Publication Date:
September 02, 2021
Filing Date:
February 25, 2021
Export Citation:
Assignee:
CHONG KUN DANG PHARMACEUTICAL CORP (KR)
International Classes:
C07D471/04; A61K31/437; A61K31/4545; A61K31/496; A61K31/506; A61P3/00; A61P11/00; A61P25/00; A61P27/02; A61P31/00
Domestic Patent References:
| WO2011038086A2 | 2011-03-31 | |||
| WO2013066835A2 | 2013-05-10 |
Foreign References:
| US20100120761A1 | 2010-05-13 | |||
| US20180230114A1 | 2018-08-16 | |||
| US20120041000A1 | 2012-02-16 |
Other References:
See also references of EP 4110781A4
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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