Title:
1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/018733
Kind Code:
A1
Abstract:
A 1,5-naphthyridine derivative represented by general formula [1] (wherein each of R1, R2, R3, R4 and R5 represents a hydrogen atom, an -L-Z group (wherein Z represents a non-aromatic heterocyclic group or the like, and L represents a single bond or the like) or the like; R6 represents an -L-Z group or the like; each of R7 and R8 represents a hydrogen atom or the like; and Q represents an oxygen atom or the like) or a salt thereof has excellent inhibitory activity against the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for the prophylaxis or treatment of diseases associated with the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway.
Inventors:
FURUYAMA HIDETOMO (JP)
KURIHARA HIDEKI (JP)
FURUYA KENTAROU (JP)
TERAO TAKAHIRO (JP)
SEKINE SHINICHIROU (JP)
NAKAGAWA DAISUKE (JP)
KURIHARA HIDEKI (JP)
FURUYA KENTAROU (JP)
TERAO TAKAHIRO (JP)
SEKINE SHINICHIROU (JP)
NAKAGAWA DAISUKE (JP)
Application Number:
PCT/JP2012/069246
Publication Date:
February 07, 2013
Filing Date:
July 27, 2012
Export Citation:
Assignee:
FUJIFILM CORP (JP)
FURUYAMA HIDETOMO (JP)
KURIHARA HIDEKI (JP)
FURUYA KENTAROU (JP)
TERAO TAKAHIRO (JP)
SEKINE SHINICHIROU (JP)
NAKAGAWA DAISUKE (JP)
FURUYAMA HIDETOMO (JP)
KURIHARA HIDEKI (JP)
FURUYA KENTAROU (JP)
TERAO TAKAHIRO (JP)
SEKINE SHINICHIROU (JP)
NAKAGAWA DAISUKE (JP)
International Classes:
A61K31/4375; C07D471/04; A61K31/444; A61K31/4709; A61K31/496; A61K31/5377; A61P5/00; A61P9/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D519/00
Domestic Patent References:
| WO2011064250A1 | 2011-06-03 | |||
| WO2011064250A1 | 2011-06-03 | |||
| WO2009097233A1 | 2009-08-06 | |||
| WO2008148867A2 | 2008-12-11 | |||
| WO2008139161A1 | 2008-11-20 | |||
| WO2005121110A1 | 2005-12-22 | |||
| WO2006125972A1 | 2006-11-30 | |||
| WO2009150240A1 | 2009-12-17 | |||
| WO2009010491A1 | 2009-01-22 |
Foreign References:
| JP2005526029A | 2005-09-02 | |||
| JP2010529031A | 2010-08-26 | |||
| JP2010526794A | 2010-08-05 | |||
| JP2007504109A | 2007-03-01 | |||
| JP2009515854A | 2009-04-16 | |||
| JP2003206290A | 2003-07-22 | |||
| US20060293358A1 | 2006-12-28 | |||
| US20040204427A1 | 2004-10-14 |
Other References:
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TETRAHEDRON, vol. 65, 2009, pages 8538
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1784, no. I, 2008, pages 159 - 185
CHEMMEDCHEM, vol. 6, no. 1, 2011, pages 38 - 48
CANCER BIOLOGY & THERAPY, vol. 7, no. 2, 2008, pages 307 - 315
NATURE MEDICINE, vol. 14, no. 12, 2008, pages 1351 - 1356
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1784, no. 1, 2008, pages 159 - 185
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 696 - 926
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 16 - 366
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 533 - 646
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 60, 1995, pages 7508 - 7510
ANGEW. CHEM., INT. ED., vol. 47, 2008, pages 3552
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 6342
TETRAHEDRON, vol. 65, 2009, pages 8538
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (JP)
Nakajima 淳 (JP)
Nakajima 淳 (JP)
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