Title:
150-CAVITY-TARGETED OSELTAMIVIR DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/233309
Kind Code:
A1
Abstract:
Disclosed in the present invention are a 150-cavity-targeted Oseltamivir derivative, a preparation method therefor, and an application thereof. The derivative has a structure represented by general formula I or II. Also disclosed in the present invention are a preparation method for the Oseltamivir derivative, an application of the Oseltamivir derivative as an anti-influenza virus inhibitor, and an application of a composition containing one or more such compounds in the preparation of an anti-influenza virus drug.
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Inventors:
LIU XINYONG (CN)
JU HAN (CN)
ZHAN PENG (CN)
HOU LINGXIN (CN)
ZHANG YING (CN)
JU HAN (CN)
ZHAN PENG (CN)
HOU LINGXIN (CN)
ZHANG YING (CN)
Application Number:
PCT/CN2022/091069
Publication Date:
November 10, 2022
Filing Date:
May 06, 2022
Export Citation:
Assignee:
SHAN DONG UNIV (CN)
International Classes:
C07C233/52; A61K31/196; A61K31/4045; A61P31/16; C07C231/12; C07D209/08; C07D307/79
Domestic Patent References:
| WO2020259471A1 | 2020-12-30 |
Foreign References:
| CN113214105A | 2021-08-06 | |||
| CN107056636A | 2017-08-18 | |||
| CN103923060A | 2014-07-16 | |||
| CN102659615A | 2012-09-12 | |||
| CN106117077A | 2016-11-16 |
Other References:
JU HAN, MURUGAN N. ARUL, HOU LINGXIN, LI PING, GUIZZO LAURA, ZHANG YING, BERTAGNIN CHIARA, KONG XIUJIE, KANG DONGWEI, JIA RUIFANG,: "Identification of C5-NH 2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 24, 23 December 2021 (2021-12-23), US , pages 17992 - 18009, XP055983080, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01366
Attorney, Agent or Firm:
JINAN JINDI INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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