16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS

WIPO Patent Application WO2000047603

A9

The invention relates to novel compounds as pharmaceutical agents which have in vitro a higher affinity to estrogen receptor preparations of the rat prostate than to estrogen receptor preparations of the rat uterus and which preferably have in vivo a preferential effect on bones as compared to the uterus and/or a marked effect with regard to the stimulation of the expression of the 5HT2a receptor and transporter. The invention also relates to the production and to the use in therapy of these compounds and to pharmaceutical administration forms containing said novel compounds. The novel compounds are 16 alpha and 16 beta hydroxy-estra,1,3,5(10)-estratriene which carry additional substituents at the steroid backbone and one or more additional double bonds on the B, C and/or D rings.

KUENZER HERMANN (DE)
KNAUTHE RUDOLF (DE)
LESSL MONIKA (DE)
FRITZEMEIER KARL-HEINRICH (DE)
HEGELE-HARTUNG CHRISTA (DE)
BOEMER ULF (DE)
MUELLER GERD (DE)
KOSEMUND DIRK (DE)

PCT/EP2000/001073

September 07, 2001

February 09, 2000

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SCHERING AG (DE)
KUENZER HERMANN (DE)
KNAUTHE RUDOLF (DE)
LESSL MONIKA (DE)
FRITZEMEIER KARL HEINRICH (DE)
HEGELE HARTUNG CHRISTA (DE)
BOEMER ULF (DE)
MUELLER GERD (DE)
KOSEMUND DIRK (DE)

A61P1/00; A61P5/30; A61P9/00; A61P9/10; A61P13/00; A61P13/02; A61P13/08; A61K31/565; A61P19/08; A61P19/10; A61P25/00; A61P25/20; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07J1/00; C07J15/00; C07J31/00; C07J33/00; C07J41/00; C07J53/00; (IPC1-7): C07J53/00; C07J1/00; A61K31/565; C07J31/00; C07J41/00; C07J33/00; C07J15/00

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