Title:
1,8-NAPHTHALIMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/196022
Kind Code:
A1
Abstract:
Disclosed are a 1,8-naphthalimide derivative, a preparation method therefor and a use thereof. The 1,8-naphthalimide derivative of the present invention is relatively easy to prepare, and is an enhanced Cu2+ fluorescent probe, which can detect Cu2+ by means of two wavelengths, and can be especially applied to almost-all-water systems. According to a titration experiment at 392 nm and a blank experiment at 754 nm, the detection limit of the 1,8-naphthalimide derivative of the present invention for Cu2+ is 2.6368×10-7 mol/L and 2.0156×10-7 mol/L respectively, indicating that same can perform quantitative detection for Cu2+ with a high selectivity and a high sensitivity by using two wavelengths. In addition, a pH colorimetric switch based on 1,8-naphthalimide can rapidly and reversibly respond to a pH by means of three ways: a maximum absorption wavelength, absorbance and color change. Same has a narrow switching pH range (from a pH of 5.8 to a pH of 6.0, only 0.2 pH units), a good selectivity and a high sensitivity, can be used in almost-all-water systems, and has a bright application prospective.
Inventors:
XU DONGMEI (CN)
CHEN YUFEN (CN)
CHEN YUFEN (CN)
Application Number:
PCT/CN2018/082584
Publication Date:
October 17, 2019
Filing Date:
April 10, 2018
Export Citation:
Assignee:
ZHANGJIAGANG INST IND TECH SOOCHOW UNIV (CN)
UNIV SOOCHOW (CN)
UNIV SOOCHOW (CN)
International Classes:
C07D221/14; C09K11/06; G01N21/64
Foreign References:
| CN103664971A | 2014-03-26 | |||
| CN107501179A | 2017-12-22 | |||
| CN106518870A | 2017-03-22 | |||
| CN106478602A | 2017-03-08 | |||
| CN102533255A | 2012-07-04 | |||
| CN108395403A | 2018-08-14 | |||
| CN108387544A | 2018-08-10 |
Other References:
CHEN, JIAY I ET AL.: "1, 8- Naphthalimide-based turn-on fluorescent cnemose sor for Cu2+ and its application in bioimaging", JOURNAL OF LUMINESCENCE, 24 August 2016 (2016-08-24), pages 301 - 305, ISSN: 0022-2313
CHEN, ZHIJUN ET AL.: "Highly selective fluorescence turn-on chemosensor ba on naphthalimide derivatives for detection of copper(II) ions", SPECTROCHIMICA ACTA, PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol. 105, 2013, pages 57 - 61, XP055643432, ISSN: 1386-1425
CHEN, ZHIJUN ET AL.: "Highly selective fluorescence turn-on chemosensor ba on naphthalimide derivatives for detection of copper(II) ions", SPECTROCHIMICA ACTA, PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol. 105, 2013, pages 57 - 61, XP055643432, ISSN: 1386-1425
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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