Title:
2-(4-ETHYLPHENOXY)-4'-METHOXY-3,3'-BIPYRIDINE CRYSTAL AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/027162
Kind Code:
A1
Abstract:
Provided is a 2-(4-ethylphenoxy)-4'-methoxy-3,3'-bipyridine (compound (I)) crystal that has superior stability and that is suitable as an active pharmaceutical ingredient of a drug. A suspension of the compound (I) is prepared by employing the compound (I) and a solvent containing 2-propanol, and the suspension is agitated and is subsequently filtered. An obtained compound (I) crystal (in particular, Form A) has a high purity and a high bulk density and is particularly superior as an active pharmaceutical ingredient of a drug.
Inventors:
YAMADA TAKUYA (JP)
KANAYAMA TAKESHI (JP)
KANAYAMA TAKESHI (JP)
Application Number:
PCT/JP2022/032144
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
KAKEN PHARMA CO LTD (JP)
International Classes:
A61K31/444; C07D213/68; A61P31/10
Domestic Patent References:
| WO2017047602A1 | 2017-03-23 |
Foreign References:
| JP2018145180A | 2018-09-20 | |||
| JP2006008553A | 2006-01-12 | |||
| JP2018504414A | 2018-02-15 | |||
| JP2019522015A | 2019-08-08 |
Other References:
ASHIZAWA, KAZUHIDE: "IYAKUHIN NO TAKEI GENSHO TO SHOSEKI NO KAGAKU", 20 September 2002, MARUZEN CO., LTD. PUBLISHING DIVISION , JP , ISBN: 978-4-901689-06-9, article ASHIZAWA, KAZUHIDE: "Passage, Polymorphism and crystallization of the pharmaceutical drugs", pages: 305 - 317, XP009527171
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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