2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Title:

2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2002022559

Kind Code:

A3

Abstract:

The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

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Inventors:

DURLEY RICHARD C (US)
SIKORSKI JAMES (US)
HANSEN DONALD JR (US)
PROMO MICHELLE A (US)
WEBBER RONALD KEITH (US)
PITZELE BARNETT S (US)
AWASTHI ALOK K (US)
MOORMAN ALAN E (US)

Application Number:

PCT/US2001/028733

Publication Date:

January 23, 2003

Filing Date:

September 15, 2001

Export Citation:

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Assignee:

PHARMACIA CORP (US)
DURLEY RICHARD C (US)
SIKORSKI JAMES (US)
HANSEN DONALD JR (US)
PROMO MICHELLE A (US)
WEBBER RONALD KEITH (US)
PITZELE BARNETT S (US)
AWASTHI ALOK K (US)
MOORMAN ALAN E (US)

International Classes:

A61K31/198; A61K31/4245; A61P19/02; A61P29/00; C07C229/30; C07C251/08; C07C251/16; C07D271/06; C07C251/24; C07C255/30; C07C257/14; C07C259/14; C07C271/22; C07D209/48; C07D271/07; C07D413/06; (IPC1-7): C07C251/08; C07C229/30; C07C271/22; C07C255/30; A61K31/201; A61P19/02; C07D209/48

Domestic Patent References:

WO1999046240A2	1999-09-16
WO1995025717A1	1995-09-28

Other References:

YOUNG R J R J ET AL: "Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 6, March 2000 (2000-03-01), pages 597 - 600, XP004190946, ISSN: 0960-894X
LEE, Y ET AL: "Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 7, 1999, ELSEVIER SCIENCE LTD., GB, pages 1097 - 1104, XP002197284, ISSN: 0968-0896
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002197442, Database accession no. 88063
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002197443, Database accession no. 1532257
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002197444, Database accession no. 1072342

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