2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF

WIPO Patent Application WO/2021/000884

A1

The present invention relates to a 2-aminopyrimidine compound shown in formula I, a pharmaceutically acceptable salt, solvate or prodrug thereof, preparation methods for the 2-aminopyrimidine compound, and the pharmaceutically acceptable salt, solvate or prodrug thereof, and a pharmaceutical composition comprising the compound. Substituents R1, R2, R3, R4, X, Y, Z, Q, m, and n have meanings given in the description. The present invention further relates to the application of the compound of formula I in the preparation of a medication for treating and/or preventing a malignant hematologic disease and other proliferative diseases.

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ZHAO YANFANG (CN)
LI YINGXIU (CN)
QIN MINGZE (CN)
HOU YUNLEI (CN)
LIU YAJING (CN)
GONG PING (CN)

PCT/CN2020/099683

January 07, 2021

July 01, 2020

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UNIV SHENYANG PHARMACEUTICAL (CN)

C07D239/48; A61K31/506; A61K31/5377; A61K31/541; A61P35/00; A61P35/02; C07D401/14; C07D413/12

CN111423384A	2020-07-17
CN110317176A	2019-10-11
CN110862376A	2020-03-06
CN104540809A	2015-04-22
CN109776522A	2019-05-21
CN101679440A	2010-03-24
CN109311896A	2019-02-05
CN201910598383A	2019-07-04

LI, YINGXIU ET AL.: "Discovery of 4-piperazinyl-2-aminopyrimidine Derivatives as Dual Inhibitors of JAK2 and FLT3", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 181, 7 August 2019 (2019-08-07), XP085857459, ISSN: 1768-3254
DATABASE Registry 29 January 2017 (2017-01-29), ANONYMOUS: "Ethanone, 2-(4-fluorophenyl)-1-[3-[2-(2-pyrimidinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]- (CA INDEX NAME)", XP055771399, retrieved from STN Database accession no. 2060735-05-7
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794443-70-1 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-(4-fluorophenyl)-1-[3-[2-(2-pyrazinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME) ", XP055893500, retrieved from STN Database accession no. 1794443-70-1
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794228-81-1 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-(4-chlorophenyl)-1-[3-[2-(2-pyridinylamino)-4-pyrimidinyl]-1- azetidinyl]-(CA INDEX NAME)", XP055893504, retrieved from STN Database accession no. 1794228-81-1
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794158-65-8 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-phenyl-1-[3-[2-(2-pyrazinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME)", XP055893507, retrieved from STN Database accession no. 1794158-65-8
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794063-68-5 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-(4-fluorophenyl)-1-[3-[2-(2-pyridinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME)", XP055893510, retrieved from STN Database accession no. 1794063-68-5
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794063-43-6 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-phenyl-1-[3-[2-(2-pyridinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME)", XP055893516, retrieved from STN Database accession no. 1794063-43-6
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1794059-30-5 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-(4-methoxyphenyl)-1-[3-[2-(2-pyrimidinylamino)-4-pyrimidinyl]- 1-pyrrolidinyl]-(CA INDEX NAME) ", XP055893518, retrieved from STN Database accession no. 1794059-30-5
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1793980-74-1 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-(4-methoxyphenyl)-1-[3-[2-(2-pyrazinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME)", XP055893524, retrieved from STN Database accession no. 1793980-74-1
DATABASE REGISTRY 5 July 2015 (2015-07-05), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1793980-48-9 REGISTRY ED -Entered STN: 05 Jul 2015 CN -Ethanone, 2-phenyl-1-[3-[2-(2-pyrimidinylamino)-4-pyrimidinyl]-1- pyrrolidinyl]-(CA INDEX NAME)", XP055893529, retrieved from STN Database accession no. 1793980-48-9
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See also references of EP 3998254A4

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