Title:
2-AMINOPYRIMIDINE COMPOUND OR SALT, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143482
Kind Code:
A1
Abstract:
The present invention relates to a 2-aminopyrimidine compound as shown in formula (I), a pharmaceutically acceptable salt, a tautomer, a stereoisomer, a solvate or a prodrug thereof, a preparation method therefor, and a pharmaceutical composition comprising same. The present invention also relates to a method for treating or preventing cyclin-dependent kinase 12 (CDK12)-related diseases or disorders, and a use of the compound in the preparation of a drug for treating or preventing CDK12-related diseases or disorders.
Inventors:
WANG YONGHUI (CN)
YU FAZHI (CN)
CHENG YAOBANG (CN)
CHEN WEI (CN)
YU FAZHI (CN)
CHENG YAOBANG (CN)
CHEN WEI (CN)
Application Number:
PCT/CN2023/073500
Publication Date:
August 03, 2023
Filing Date:
January 28, 2023
Export Citation:
Assignee:
SHANGHAI LITEDD CO LTD (CN)
International Classes:
A61K31/506; C07D401/14; A61P9/00; A61P31/00; A61P35/00; C07D403/14; C07D405/14
Domestic Patent References:
| WO2022149057A1 | 2022-07-14 | |||
| WO2020224568A1 | 2020-11-12 | |||
| WO2017163076A1 | 2017-09-28 | |||
| WO2020023782A1 | 2020-01-30 | |||
| WO2020206137A1 | 2020-10-08 | |||
| WO2021155050A1 | 2021-08-05 |
Foreign References:
| CN114539225A | 2022-05-27 | |||
| CN113993519A | 2022-01-28 |
Other References:
JIANG BAISHAN, JIANG JIE, KALTHEUNER INES H., INIGUEZ AMANDA BALBONI, ANAND KANCHAN, FERGUSON FLEUR M., FICARRO SCOTT B., SEONG BO: "Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 221, 1 October 2021 (2021-10-01), AMSTERDAM, NL , pages 113481, XP093048367, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113481
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