Title:
2'-DEOXY-7-DEAZAPURINE NUCLEOSIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/110591
Kind Code:
A1
Abstract:
The present invention makes it clear that a nucleoside derivative which shows excellent antiviral activity against HBV and which has low cytotoxicity can be obtained by substituting specific functional groups at each of positions 2, 6, and 7 of the purine base and position 4 of the ribose sugar, in 2'-deoxy-7-deazaadenosine.
Inventors:
MITSUYA HIROAKI (JP)
YAMADA KOHEI (JP)
TOMAYA KOTA (JP)
OHNO YUTARO (JP)
YAMADA KOHEI (JP)
TOMAYA KOTA (JP)
OHNO YUTARO (JP)
Application Number:
PCT/JP2017/044684
Publication Date:
June 21, 2018
Filing Date:
December 13, 2017
Export Citation:
Assignee:
YAMASA CORP (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
C07H19/14; A61K31/7064; A61P31/12
Domestic Patent References:
| WO2015199136A1 | 2015-12-30 | |||
| WO2005020885A2 | 2005-03-10 | |||
| WO2016100569A1 | 2016-06-23 |
Foreign References:
| US5844106A | 1998-12-01 | |||
| US6004939A | 1999-12-21 | |||
| JP2013159574A | 2013-08-19 | |||
| JP2007029093A | 2007-02-08 | |||
| JP2005514401A | 2005-05-19 | |||
| JP2005538096A | 2005-12-15 | |||
| US5192749A | 1993-03-09 |
Other References:
S EELA, F. ET AL.: "7-Substituted 7-deaza-2'-deoxyadenosines and 8-aza-7-deaza 2'-deoxyadenosines:Fluorescence of DNA-Base Analogues Induced by the 7-Alkynyl Side Chain", HELVETICA CHIMICA ACTA, vol. 83, 2000, pages 910 - 927, XP002318798
RAINDLOVA, V. ET AL., CHEMPLUSCHEM, vol. 77, 2012, pages 652 - 662
SEELA, F. ET AL.: "Hydrogelation and spontaneous fiber formation of 8-aza-7-deazaadenine nucleoside click conjugates", TETRAHEDRON, vol. 67, 2011, pages 7418 - 7425, XP028265664
PENG, X. ET AL., NUCLEIC ACIDS RESEARCH, vol. 34, no. 20, 2006, pages 5987 - 6000
NAUS, P. ET AL.: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines:20-C-methylribonucleosides, 20-deoxy-20-fluoroarabinonucleosides,arabinonucleosides and 20-deoxyribonucleosides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 5202 - 5214, XP055496940
T AKAMATSU ET AL., HEPATOLOGY, vol. 62, no. 4, 2015, pages 1024 - 1036
RAINDLOVA, V. ET AL., CHEMPLUSCHEM, vol. 77, 2012, pages 652 - 662
SEELA, F. ET AL.: "Hydrogelation and spontaneous fiber formation of 8-aza-7-deazaadenine nucleoside click conjugates", TETRAHEDRON, vol. 67, 2011, pages 7418 - 7425, XP028265664
PENG, X. ET AL., NUCLEIC ACIDS RESEARCH, vol. 34, no. 20, 2006, pages 5987 - 6000
NAUS, P. ET AL.: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines:20-C-methylribonucleosides, 20-deoxy-20-fluoroarabinonucleosides,arabinonucleosides and 20-deoxyribonucleosides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 5202 - 5214, XP055496940
T AKAMATSU ET AL., HEPATOLOGY, vol. 62, no. 4, 2015, pages 1024 - 1036
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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