Title:
(2-HYDROXY)ETHYL-THIOUREAS USEFUL AS MODULATORS OF ALPHA2B ADRENERGIC RECEPTORS
Document Type and Number:
WIPO Patent Application WO2002068384
Kind Code:
A3
Abstract:
Compounds of formula (i) and of formula (ii), wherein the symbols have the meaning disclosed in the claims, specifically or selectively modulate alpha 2A adrenergic receptors and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardiovascular and/or sedatory activity. The invention also relates to a method of activating alpha 2B or alpha 2C adrenergic receptors in a mammal by administering a compound that has alpha 2Bor alpha 2C adrenergic receptor activity and has no significant alpha 2A agonist activity.
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Inventors:
CHOW KEN
GIL DANIEL W
FANG WENKUI KEN
GARST MICHAEL E
GIL DANIEL W
FANG WENKUI KEN
GARST MICHAEL E
Application Number:
PCT/US2002/005021
Publication Date:
March 06, 2003
Filing Date:
February 19, 2002
Export Citation:
Assignee:
ALLERGAN INC (US)
International Classes:
A61P29/00; C07C335/08; C07C335/10; C07C335/14; (IPC1-7): C07C335/08; C07C335/10; C07C335/14; A61K31/17; A61P29/00
Domestic Patent References:
| WO1995011021A1 | 1995-04-27 |
Other References:
J.W. LOWN, ET AL.: "Synthesis of novel-N-nitrosothioureas and examination of their mechanisms of formation by high-field nitrogen-15 and carbon-13 nuclear magnetic resonance spectra of specifically labelled compounds", JOURNAL OF ORGANIC CHEMISTRY, vol. 48, no. 4, 25 February 1983 (1983-02-25), American Chemical Society, Washington, DC, US, pages 507 - 512, XP002222322, ISSN: 0022-3263
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