Title:
2-METHYL-2-THIAZOLINE SALT
Document Type and Number:
WIPO Patent Application WO/2023/219106
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a solid derivative of 2-methyl-2-thiazoline that is easy to handle during formulation and is useful as an active pharmaceutical ingredient. The present invention provides: a 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, or a deuterated product thereof; a pharmaceutical composition and a prophylactic or therapeutic agent for hypoxic damage, ischemia-reperfusion injury, or inflammation that contain said substance; and a method for producing a 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, or a deuterated product thereof.
Inventors:
TANIGAWA KIYOSHI (JP)
MARUHASHI KAZUO (JP)
MARUHASHI KAZUO (JP)
Application Number:
PCT/JP2023/017574
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
MYRODIA THERAPEUTICS CO LTD (JP)
International Classes:
C07D277/10; A61K31/426; A61P9/10; A61P29/00
Domestic Patent References:
| WO2019177142A1 | 2019-09-19 |
Foreign References:
| JP2008510754A | 2008-04-10 | |||
| JP2011524897A | 2011-09-08 | |||
| JP2021512118A | 2021-05-13 | |||
| JP2012529064A | 2012-11-15 | |||
| GB1170841A | 1969-11-19 | |||
| US2813862A | 1957-11-19 |
Other References:
BUTEAU K C: "Deuterated Drugs: Unexpectedly Nonobvious?", JOURNAL OF HIGH TECHNOLOGY LAW, SUFFOLK UNIVERSITY LAW SCHOOL,, US, vol. X, no. 1, 1 January 2009 (2009-01-01), US , pages 22 - 74, XP002636702, ISSN: 1536-7983
HELMKAMP G. K., DAVID J. PETTITT, JAMES R. LOWELL JR., WILLIAM R. MABEY, AND ROBERT G. WOLCOTT: "A General, Stereospecific Synthetic Route to π2-Thiazolines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 88, no. 5, 1 March 1966 (1966-03-01), pages 1030 - 1033, XP093106261
KUHN RICHARD, DRAWERT FRIEDRICH: "Über Thiazoline", JUSTUS LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH., DE, vol. 590, no. 1, 30 November 1954 (1954-11-30), DE , pages 55 - 75, XP093106264, ISSN: 0075-4617, DOI: 10.1002/jlac.19545900104
SCHMIR GASTON L: "The Effect of Structural Variation on the Hydrolysis of 12-Thiazolines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 87, no. 12, 1 January 1965 (1965-01-01), pages 2743 - 2751, XP093106739
HELMKAMP G. K., DAVID J. PETTITT, JAMES R. LOWELL JR., WILLIAM R. MABEY, AND ROBERT G. WOLCOTT: "A General, Stereospecific Synthetic Route to π2-Thiazolines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 88, no. 5, 1 March 1966 (1966-03-01), pages 1030 - 1033, XP093106261
KUHN RICHARD, DRAWERT FRIEDRICH: "Über Thiazoline", JUSTUS LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH., DE, vol. 590, no. 1, 30 November 1954 (1954-11-30), DE , pages 55 - 75, XP093106264, ISSN: 0075-4617, DOI: 10.1002/jlac.19545900104
SCHMIR GASTON L: "The Effect of Structural Variation on the Hydrolysis of 12-Thiazolines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 87, no. 12, 1 January 1965 (1965-01-01), pages 2743 - 2751, XP093106739
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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