2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS

Title:

2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS

Document Type and Number:

WIPO Patent Application WO2004078746

Kind Code:

A3

Abstract:

This invention relates to novel diaryl ureas of formula (I), pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

Inventors:

BOYER STEPHEN (DE)
DUMAS JACQUES (US)
PHILLIPS BARTON (US)
SCOTT WILLIAM J (US)
SMITH ROGER A (US)
CHEN JIANQING (US)
JAMES BENJAMIN (US)
WANG GAN (US)

Application Number:

PCT/US2004/006283

Publication Date:

December 02, 2004

Filing Date:

March 01, 2004

Export Citation:

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Assignee:

BAYER PHARMACEUTICALS CORP (US)
BOYER STEPHEN (DE)
DUMAS JACQUES (US)
PHILLIPS BARTON (US)
SCOTT WILLIAM J (US)
SMITH ROGER A (US)
CHEN JIANQING (US)
JAMES BENJAMIN (US)
WANG GAN (US)

International Classes:

A61K31/35; A61P35/00; C07D213/00; C07D251/00; C07D401/12; (IPC1-7): C07D401/12; A61K31/35; A61P35/00

Domestic Patent References:

WO2001057008A1	2001-08-09
WO2001036403A1	2001-05-25
WO2000043384A1	2000-07-27
WO1999032106A1	1999-07-01
WO2002062763A2	2002-08-15

Other References:

DUMAS J: "PROTEIN KINASE INHIBITORS FROM THE UREA CLASS", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, CURRENT DRUGS, LONDON, GB, vol. 5, no. 5, 2002, pages 718 - 727, XP009011493, ISSN: 1367-6733

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