Title:
2-OXO-3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/061492
Kind Code:
A1
Abstract:
Provided are a compound of formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or an isotope marker thereof; a pharmaceutical composition containing the compound of formula (I); and the use of the compound of formula (I) or the pharmaceutical composition thereof in the treatment of KHK-mediated diseases.
Inventors:
CHEN LI (CN)
LI HONGBIN (CN)
LI JIN (CN)
JIANG PEIPEI (CN)
LI HONGBIN (CN)
LI JIN (CN)
JIANG PEIPEI (CN)
Application Number:
PCT/CN2022/125431
Publication Date:
April 20, 2023
Filing Date:
October 14, 2022
Export Citation:
Assignee:
HUA MEDICINE SHANGHAI LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P25/02; A61P37/00; C07D403/04; C07D403/14
Domestic Patent References:
| WO2021081375A1 | 2021-04-29 |
Foreign References:
| CN108473469A | 2018-08-31 | |||
| CN106470973A | 2017-03-01 |
Other References:
MOLCHANOV S. A., STEPAKOV A. V., KOSTIKOV R. R.: "ChemInform Abstract: Thermolysis of the Esters of Substituted 3,7-Triazabicyclo[3.3.0]oct-3-ene-4-carboxylic Acids.", CHEMINFORM, ELECTROCHEMICAL SOCIETY, vol. 32, no. 17, 24 April 2001 (2001-04-24), pages no - no, XP093058652, ISSN: 0931-7597, DOI: 10.1002/chin.200117039
MOLCHANOV ALEXANDER P., STEPAKOV ALEXANDER V., KOSTIKOV RAFAEL R., BAIRD MARK S.: "A New Synthetic Route to 1-Halogeno-1-cyclopropanecarboxylates", SYNLETT, GEORG THIEME VERLAG, DE, vol. 2000, no. 2, 1 February 2000 (2000-02-01), DE , pages 219 - 220, XP093058655, ISSN: 0936-5214, DOI: 10.1055/s-2000-6495
MOLCHANOV ALEXANDER P., STEPAKOV ALEXANDER V., KOSTIKOV RAFAEL R., BAIRD MARK S.: "A New Synthetic Route to 1-Halogeno-1-cyclopropanecarboxylates", SYNLETT, GEORG THIEME VERLAG, DE, vol. 2000, no. 2, 1 February 2000 (2000-02-01), DE , pages 219 - 220, XP093058655, ISSN: 0936-5214, DOI: 10.1055/s-2000-6495
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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