Title:
2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO2003032984
Kind Code:
A8
Abstract:
2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines of formula (I) are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. wherein W is COOH, -(CO)NHR<1>, or -(SO2)NHR<1> R<1> is H or C1-4alkyl; Q is N or CH; Ra and Rb are H or halogen; Y, Y1 and Y2 are independently selected from N and C-Rc with the proviso that 0, 1 or 2 of Y, Y1 and Y2 are N and at least 2 of Rc must be hydrogen; Rc are independently selected from the group consiting of -H, -OH, -C1-6alkyl, -SCF3, halo, -CF3 and -OCF3; Z is selected from the group consisting of O, S, SO, SO2, SO2NR<2>, NR<2>SO2, NH, CONR<2>, piperazin-diyl or a covalent bond; R<2> is H or C1-4alkyl; AR1 is an aromatic group as defined in the claims.
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Inventors:
ARIENTI KRISTEN L
AXE FRANK U
BREITENBUCHER J GUY
HUANG LIMING
LEE ALICE
MCCLURE KELLY J
AXE FRANK U
BREITENBUCHER J GUY
HUANG LIMING
LEE ALICE
MCCLURE KELLY J
Application Number:
PCT/US2002/033371
Publication Date:
November 20, 2003
Filing Date:
October 18, 2002
Export Citation:
Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
A61K31/4184; A61K31/437; A61K31/4439; A61K31/4745; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K41/00; A61K45/00; A61P35/00; A61P43/00; C07D235/18; C07D401/04; C07D401/10; C07D401/12; C07D403/04; C07D405/12; C07D471/02; C07D471/04; (IPC1-7): A61K31/4184; A61K31/4439; A61K31/437; A61K31/496; A61K31/5377; C07D235/18; C07D471/04; C07D401/04; C07D401/10; C07D295/12; C07D295/14; C07D401/12; C07D405/12
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