Title:
2-PROPYLIDENE-19-NOR-VITAMIN D COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2004092118
Kind Code:
A3
Abstract:
2-propylidene-19-nor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by high bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. These compounds also increase both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
Inventors:
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
GLEBOCKA AGNIESZKA (PL)
PLUM LORI A (US)
SICINSKI RAFAL R (PL)
GLEBOCKA AGNIESZKA (PL)
PLUM LORI A (US)
Application Number:
PCT/US2004/011059
Publication Date:
January 27, 2005
Filing Date:
April 09, 2004
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
GLEBOCKA AGNIESZKA (PL)
PLUM LORI A (US)
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
GLEBOCKA AGNIESZKA (PL)
PLUM LORI A (US)
International Classes:
A61P1/00; A61P17/06; A61P19/08; A61P19/10; A61P29/00; A61P35/00; A61P35/02; A61P37/00; C07F7/18; (IPC1-7): C07C401/00; C07F7/18; C07F9/53; A61K31/593; A61P19/08; A61P17/06; A61P35/00; A61P35/02; A61P37/00; A61P1/00; A61P29/00; A61P19/10
Foreign References:
| US20020087015A1 | 2002-07-04 | |||
| US6392071B1 | 2002-05-21 | |||
| US5936133A | 1999-08-10 | |||
| US5843928A | 1998-12-01 |
Download PDF: