Title:
2-PYRIDONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/068211
Kind Code:
A1
Abstract:
2-Pyridone compounds represented by general formula [1], tautomers or stereoisomer thereof, pharmaceutically acceptable salts of the same, or solvates thereof have excellent GK-activating activity and therefore are useful as drugs. In general formula [1], A is a benzene ring or a pyridine ring; X is a structure represented by general formula [3]; V is a single bond or lower alkylene; W is a single bond, an ether linkage, or lower alkylene (which may contain an ether linkage).
Inventors:
KAWAGUCHI TAKANORI (JP)
WATATANI KENGO (JP)
FUSEGI KEIKO (JP)
BOHNO MASAHIRO (JP)
ASANUMA HAJIME (JP)
KURODA SHOICHI (JP)
IMAI YUDAI (JP)
CHONAN TOMOMICHI (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)
SASAKO SHIGETADA (JP)
OKADA TAKUMI (JP)
HAYASHI KEISHI (JP)
ITOH SHIN (JP)
SAITO NORIKO (JP)
JIBIKI RUI (JP)
ISHIYAMA SEISHI (JP)
OTA HIROFUMI (JP)
WATATANI KENGO (JP)
FUSEGI KEIKO (JP)
BOHNO MASAHIRO (JP)
ASANUMA HAJIME (JP)
KURODA SHOICHI (JP)
IMAI YUDAI (JP)
CHONAN TOMOMICHI (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)
SASAKO SHIGETADA (JP)
OKADA TAKUMI (JP)
HAYASHI KEISHI (JP)
ITOH SHIN (JP)
SAITO NORIKO (JP)
JIBIKI RUI (JP)
ISHIYAMA SEISHI (JP)
OTA HIROFUMI (JP)
Application Number:
PCT/JP2010/071709
Publication Date:
June 09, 2011
Filing Date:
December 03, 2010
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
NISSAN CHEMICAL IND LTD (JP)
KAWAGUCHI TAKANORI (JP)
WATATANI KENGO (JP)
FUSEGI KEIKO (JP)
BOHNO MASAHIRO (JP)
ASANUMA HAJIME (JP)
KURODA SHOICHI (JP)
IMAI YUDAI (JP)
CHONAN TOMOMICHI (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)
SASAKO SHIGETADA (JP)
OKADA TAKUMI (JP)
HAYASHI KEISHI (JP)
ITOH SHIN (JP)
SAITO NORIKO (JP)
JIBIKI RUI (JP)
ISHIYAMA SEISHI (JP)
OTA HIROFUMI (JP)
NISSAN CHEMICAL IND LTD (JP)
KAWAGUCHI TAKANORI (JP)
WATATANI KENGO (JP)
FUSEGI KEIKO (JP)
BOHNO MASAHIRO (JP)
ASANUMA HAJIME (JP)
KURODA SHOICHI (JP)
IMAI YUDAI (JP)
CHONAN TOMOMICHI (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)
SASAKO SHIGETADA (JP)
OKADA TAKUMI (JP)
HAYASHI KEISHI (JP)
ITOH SHIN (JP)
SAITO NORIKO (JP)
JIBIKI RUI (JP)
ISHIYAMA SEISHI (JP)
OTA HIROFUMI (JP)
International Classes:
C07D213/64; A61K31/4412; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/10; A61P19/06; A61P25/00; A61P27/02; A61P43/00; C07D401/10; C07D401/12; C07D405/10
Domestic Patent References:
| WO2009040288A1 | 2009-04-02 |
Foreign References:
| JP2009532379A | 2009-09-10 | |||
| JP2002508355A | 2002-03-19 | |||
| JPS63166855A | 1988-07-11 |
Other References:
BERGLUND, S.: "Optimization of 2-piperidin-4-yl- acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 15, 2009, pages 4268 - 4273
JONES, W. D., JR.: "A Convenient Synthesis of 5-Acyl-6-substituted 3-Cyano-2(1H)-pyridinones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, no. 3, 1990, pages 511 - 518
CORSARO, A. ET AL.: "Cycloadducts of benzonitrile oxide to pyridine. A case of a two-step cycloaddition", TETRAHEDRON LETTERS, vol. 27, no. 13, 1986, pages 1517 - 1520
RATEB, L.: "Reactions of Hydroxymethylene Ketones. Part III. Synthesis of 1,2-Dihydro-2- oxo-pyridine Polycarboxylic Acids", JOURNAL OF THE CHEMICAL SOCIETY (C) ORGANIC CHEMISTRY, 1968, pages 2140 - 2144
See also references of EP 2508513A4
JONES, W. D., JR.: "A Convenient Synthesis of 5-Acyl-6-substituted 3-Cyano-2(1H)-pyridinones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, no. 3, 1990, pages 511 - 518
CORSARO, A. ET AL.: "Cycloadducts of benzonitrile oxide to pyridine. A case of a two-step cycloaddition", TETRAHEDRON LETTERS, vol. 27, no. 13, 1986, pages 1517 - 1520
RATEB, L.: "Reactions of Hydroxymethylene Ketones. Part III. Synthesis of 1,2-Dihydro-2- oxo-pyridine Polycarboxylic Acids", JOURNAL OF THE CHEMICAL SOCIETY (C) ORGANIC CHEMISTRY, 1968, pages 2140 - 2144
See also references of EP 2508513A4
Attorney, Agent or Firm:
ASAMURA Kiyoshi et al. (JP)
Hiroshi Asamura (JP)
Hiroshi Asamura (JP)
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