Title:
(20S)-1ALPHA-HYDROXY-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL AND ITS USES
Document Type and Number:
WIPO Patent Application WO2003051828
Kind Code:
A3
Abstract:
This invention discloses (20S)-1 alpha -hydroxy-2-methylene-19-nor-bishomopregnacalciferol, pharmaceutical uses therefor, and a method of purifying this compound to obtain it in crystalline form. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
Inventors:
DELUCA HECTOR F
PLUM LORI A
CLAGETT-DAME MARGARET
THODEN JAMES B
HOLDEN HAZEL M
GOWLUGARI SUMITHRA
GRZYWACZ PAWEL
PLUM LORI A
CLAGETT-DAME MARGARET
THODEN JAMES B
HOLDEN HAZEL M
GOWLUGARI SUMITHRA
GRZYWACZ PAWEL
Application Number:
PCT/US2002/039715
Publication Date:
September 12, 2003
Filing Date:
December 12, 2002
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
International Classes:
A61K31/593; A61K31/59; A61P1/00; A61P3/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; C07C401/00; (IPC1-7): C07C401/00; A61K31/59; A61P11/06; A61P17/06; A61P35/00; A61P29/00; A61P37/00
Domestic Patent References:
| WO2001074766A1 | 2001-10-11 | |||
| WO1998041501A1 | 1998-09-24 | |||
| WO1986006255A1 | 1986-11-06 | |||
| WO2002020021A1 | 2002-03-14 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OSTREM, VOULA K. ET AL: "Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs", XP002238137, retrieved from STN Database accession no. 107:191147
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DELUCA, HECTOR F. ET AL: "Analogs of the hormonal form of vitamin D and their possible use in leukemia", XP002238138, retrieved from STN Database accession no. 108:180270
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HEKUTAA, EFU DERUUKA ET AL: "Cell differentiation-inducing agents containing secosterols", XP002238139, retrieved from STN Database accession no. 120:153700
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DELUCA, HECTOR F. ET AL: "Analogs of the hormonal form of vitamin D and their possible use in leukemia", XP002238138, retrieved from STN Database accession no. 108:180270
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HEKUTAA, EFU DERUUKA ET AL: "Cell differentiation-inducing agents containing secosterols", XP002238139, retrieved from STN Database accession no. 120:153700
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