Title:
2,4-DIHYDROXYL CHALCONE DERIVATIVE, PROCESS FOR PREPARING THEM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/143714
Kind Code:
A1
Abstract:
Disclosed is a new 2,4-dihydroxyl chalcone derivative having the structure of general formula i and a pharmaceutically acceptable salt thereof, in which each group has the same meaning as defined in the specification, and a process for preparing them, a pharmaceutical composition comprising them, and their use of anti-tumor.
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Inventors:
LI YILIANG (CN)
SHI YU (CN)
LIU WEI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
ZOU MEIXIANG (CN)
HOU WENBIN (CN)
CHEN ZHILING (CN)
ZHAO LEJING (CN)
LIN XIAOMING (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
LIU BINGNI (CN)
SHI YU (CN)
LIU WEI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
ZOU MEIXIANG (CN)
HOU WENBIN (CN)
CHEN ZHILING (CN)
ZHAO LEJING (CN)
LIN XIAOMING (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
LIU BINGNI (CN)
Application Number:
PCT/CN2009/000601
Publication Date:
December 03, 2009
Filing Date:
May 27, 2009
Export Citation:
Assignee:
TIANJIN INST PHARM RESEARCH (CN)
LI YILIANG (CN)
SHI YU (CN)
LIU WEI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
ZOU MEIXIANG (CN)
HOU WENBIN (CN)
CHEN ZHILING (CN)
ZHAO LEJING (CN)
LIN XIAOMING (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
LIU BINGNI (CN)
LI YILIANG (CN)
SHI YU (CN)
LIU WEI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
ZOU MEIXIANG (CN)
HOU WENBIN (CN)
CHEN ZHILING (CN)
ZHAO LEJING (CN)
LIN XIAOMING (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
LIU BINGNI (CN)
International Classes:
C07C225/16; A61K31/122; A61P35/00; C07C221/00; C07C225/02; C07C225/14; C07D295/03
Domestic Patent References:
| WO2007133588A2 | 2007-11-22 |
Foreign References:
| CN1749237A | 2006-03-22 | |||
| CN101066963A | 2007-11-07 |
Other References:
ZHANG, SHIXUAN ET AL.: "Nitrogen-containing flavonoid analogues as CDKl/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 15, August 2008 (2008-08-01), pages 7128 - 7132
M. VIJAYA BHASKAR ET AL.: "Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 15, August 2008 (2008-08-01), pages 7358 - 7370
M. VIJAYA BHASKAR ET AL.: "Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 15, August 2008 (2008-08-01), pages 7358 - 7370
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (18th FloorTower 2, Xihuan Plaza,1 Xizhimenwai Street, Xicheng District, Beijing 4, CN)
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