Title:
2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/213211
Kind Code:
A1
Abstract:
Disclosed herein is a 2,4-disubstituted-5-fluoropyrimidine derivative having a structural general formula represented by formula I: wherein, R1 and R2 are each independently selected from: R4 is selected from:
Also disclosed herein is a method for preparing the compound and use thereof in preparing a medicament against renal interstitial fibrosis.
Inventors:
LI QIANBIN (CN)
HU GAOYUN (CN)
CHEN ZHUO (CN)
TAO LIJIAN (CN)
PENG ZHANGZHE (CN)
HU GAOYUN (CN)
CHEN ZHUO (CN)
TAO LIJIAN (CN)
PENG ZHANGZHE (CN)
Application Number:
PCT/CN2023/090579
Publication Date:
November 09, 2023
Filing Date:
April 25, 2023
Export Citation:
Assignee:
CHANGSHA JINGYI PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D403/04; A61K31/506; A61P13/12; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12
Domestic Patent References:
| WO2008154026A1 | 2008-12-18 |
Foreign References:
| CN116514779A | 2023-08-01 | |||
| CN105592850A | 2016-05-18 | |||
| CN114230524A | 2022-03-25 | |||
| CN102369187A | 2012-03-07 |
Other References:
ANKUSH ARGADE, SOMASEKHAR BHAMIDIPATI, HUI LI, DAVID CARROLL, JEFFREY CLOUGH, HOLGER KEIM, CATHERINE SYLVAIN, ALEXANDER B. ROSSI, : "Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 10, 1 May 2015 (2015-05-01), Amsterdam NL , pages 2117 - 2121, XP055295593, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.03.075
DATABASE Registry 29 August 2003 (2003-08-29), ANONYMOUS : "Benzoic acid, 4-[[5-fluor o-2-[[4-(methoxycar bonyl)phenyl]amin o]-4- pyrimidinyl]amino]-, methyl ester (CA IN DEX NAME) ", XP093106732, retrieved from STN Database accession no. 575479-50-4
ANKUSH ARGADE, SOMASEKHAR BHAMIDIPATI, HUI LI, DAVID CARROLL, JEFFREY CLOUGH, HOLGER KEIM, CATHERINE SYLVAIN, ALEXANDER B. ROSSI, : "Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 10, 1 May 2015 (2015-05-01), Amsterdam NL , pages 2117 - 2121, XP055295593, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.03.075
DATABASE Registry 29 August 2003 (2003-08-29), ANONYMOUS : "Benzoic acid, 4-[[5-fluor o-2-[[4-(methoxycar bonyl)phenyl]amin o]-4- pyrimidinyl]amino]-, methyl ester (CA IN DEX NAME) ", XP093106732, retrieved from STN Database accession no. 575479-50-4
ANKUSH ARGADE, SOMASEKHAR BHAMIDIPATI, HUI LI, DAVID CARROLL, JEFFREY CLOUGH, HOLGER KEIM, CATHERINE SYLVAIN, ALEXANDER B. ROSSI, : "Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 10, 1 May 2015 (2015-05-01), Amsterdam NL , pages 2117 - 2121, XP055295593, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.03.075
Attorney, Agent or Firm:
CHANGSHA ZONEKEY PATENT LAW FIRM (CN)
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