Title:
2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/099168
Kind Code:
A1
Abstract:
Disclosed is a 2,4,5-trisubstituted pyrimidine compound having a structure as represented by the formula (I) compound, an isotope labeled compound, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof: (I). Wherein R1 can be selected from one of halogen, alkyl, or alkoxy; R2 can be selected from any one of H or C1-C2 alkyl; and a plurality of substituents can be selected for R3 and R4. The compound can inhibit FGFR1 and can be used as a potential anti-tumor drug.
Inventors:
LI XIAOKUN (CN)
LIU ZHIGUO (CN)
LIN LI (CN)
ZHENG XIAOHUI (CN)
LIU ZHIGUO (CN)
LIN LI (CN)
ZHENG XIAOHUI (CN)
Application Number:
PCT/CN2023/128270
Publication Date:
May 16, 2024
Filing Date:
October 31, 2023
Export Citation:
Assignee:
UNIV WENZHOU MEDICAL (CN)
International Classes:
C07D239/48; A61K31/506; A61K31/551; A61P35/00; A61P35/02; C07D401/12; C07D403/12; C07D405/12
Attorney, Agent or Firm:
HANGZHOU ZHIXIAN PATENT AGENCY (CN)
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