Title:
3-(4-PIPERIDYL)-INDAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/038623
Kind Code:
A1
Abstract:
Provided is a therapeutic agent for diseases associated with central nervous system (CNS) and/or peripheral nervous system (PNS) cholinergicity, diseases associated with smooth muscle contraction, endocrine diseases, diseases associated with neurodegeneration, and the like, said therapeutic agent comprising a compound represented by formula (I) [wherein R1A to R1D are the same as or different from one another and independently represent an optionally substituted C1-6 alkyl group or the like; R2 represents a hydrogen atom or the like; R3A to R3E are the same as or different from one another and independently represent a hydrogen atom or the like; R4 represents an optionally substituted C1-10 alkyl group or the like; and n represents 1 or 2] or a pharmaceutically acceptable salt thereof and having a potent action of regulating an α7 nicotinic acetylcholine receptor (α7 nAChR).
Inventors:
USUI SHINYA (JP)
TAKADA TAKASHI (JP)
KITANO HIROYUKI (JP)
TAKADA TAKASHI (JP)
KITANO HIROYUKI (JP)
Application Number:
PCT/JP2013/073916
Publication Date:
March 13, 2014
Filing Date:
September 05, 2013
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
International Classes:
C07D401/04; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K45/00; A61P5/00; A61P21/00; A61P25/00; A61P25/02; A61P25/18; A61P25/28; A61P25/30; A61P29/00; A61P43/00; C07D401/14; C07D405/14
Domestic Patent References:
| WO2012176763A1 | 2012-12-27 | |||
| WO2013154109A1 | 2013-10-17 | |||
| WO2012133509A1 | 2012-10-04 | |||
| WO2004069828A1 | 2004-08-19 |
Foreign References:
| JPS60100573A | 1985-06-04 | |||
| JP2008504296A | 2008-02-14 | |||
| JPH10506914A | 1998-07-07 |
Other References:
"Tetrahedron", TETRAHEDRON, vol. 68, no. 4, 2012, pages 1286 - 1298
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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