Title:
3-((8-((1H-PYRAZOL-4-YL)AMINO)IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHINYL)-N-PHENYLBENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2021/172931
Kind Code:
A1
Abstract:
The present invention relates to a 3-((8-((1H-pyrazol-4-yl)amino)imidazo[1,2-a]pyridin-3-yl)ethinyl)-N-phenylbenzamide derivative, a method for preparing same, and a pharmaceutical composition containing same as an active ingredient for prevention or treatment of cancer, wherein the derivative can significantly inhibit the proliferation of cancer cells by inhibiting a kinase, especially, Bcr-Abl kinase or Bcr-Abl(T315I) kinase, and thus can be advantageously used as a pharmaceutical composition for prevention or treatment of cancer.
Inventors:
LEE DOOHYUN (KR)
LEE SEUNGYEON (KR)
HAN YE RI (KR)
IM CHUN YOUNG (KR)
KIM SO YOUNG (KR)
KIM NAM HUI (KR)
CHOI HWAN GEUN (KR)
KO EUNHWA (KR)
MOON HEEGYUM (KR)
LEE SUN JOO (KR)
KIM SANG BUM (KR)
KIM HYO-JI (KR)
LEE SION (KR)
AHN SUNG-MIN (KR)
CHANG KIHO (KR)
LEE EUNKYU (KR)
HUR BYUNGUNG (KR)
KWON HYUN JIN (KR)
JEONG MYEONG-SOOK (KR)
LEE SEUNGYEON (KR)
HAN YE RI (KR)
IM CHUN YOUNG (KR)
KIM SO YOUNG (KR)
KIM NAM HUI (KR)
CHOI HWAN GEUN (KR)
KO EUNHWA (KR)
MOON HEEGYUM (KR)
LEE SUN JOO (KR)
KIM SANG BUM (KR)
KIM HYO-JI (KR)
LEE SION (KR)
AHN SUNG-MIN (KR)
CHANG KIHO (KR)
LEE EUNKYU (KR)
HUR BYUNGUNG (KR)
KWON HYUN JIN (KR)
JEONG MYEONG-SOOK (KR)
Application Number:
PCT/KR2021/002452
Publication Date:
September 02, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
IMMUNOFORGE CO LTD (KR)
IMMUNOFORGE CO LTD (KR)
International Classes:
C07D471/04; A23L33/10; A61K31/437; A61K31/444; A61K31/496; A61P35/00
Domestic Patent References:
| WO2013101281A1 | 2013-07-04 | |||
| WO2013162727A1 | 2013-10-31 | |||
| WO2013170774A1 | 2013-11-21 | |||
| WO2005060969A1 | 2005-07-07 |
Foreign References:
| KR20170143456A | 2017-12-29 | |||
| KR20140016889A | 2014-02-10 | |||
| KR20130084083A | 2013-07-24 | |||
| KR101931435B1 | 2018-12-21 | |||
| KR101920456B1 | 2018-11-21 |
Other References:
ARCH PHARM RES, vol. 38, 2015, pages 893 - 903
BMB REP, vol. 44, 2011, pages 140 - 145
BMB REP, vol. 44, 2011, pages 140 - 145
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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