3-ALKANOYLAMINO-PROPIONIC ACID DERIVATIVES USED AS INHIBITORS OF INTEGRIN AVSS6

Title:

3-ALKANOYLAMINO-PROPIONIC ACID DERIVATIVES USED AS INHIBITORS OF INTEGRIN AVSS6

Document Type and Number:

WIPO Patent Application WO2003066594

Kind Code:

A3

Abstract:

The invention relates to novel biphenyl derivatives of general formula (I), in which R<1>, R<1'>, R<1"> R<2>, R<2'> R<3> and n are defined as per claim 1, to their stereoisomers and their physiologically acceptable salts or solvates. Said derivatives are novel integrin inhibitors, which preferably inhibit the avbeta6 integrin receptor. The novel compounds can be used, in particular, as medicaments.

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Inventors:

STAEHLE WOLFGANG (DE)
SCHADT OLIVER (DE)
JONCZYK ALFRED (DE)
GOODMAN SIMON (DE)

Application Number:

PCT/EP2003/000327

Publication Date:

November 27, 2003

Filing Date:

January 15, 2003

Export Citation:

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Assignee:

MERCK PATENT GMBH (DE)
STAEHLE WOLFGANG (DE)
SCHADT OLIVER (DE)
JONCZYK ALFRED (DE)
GOODMAN SIMON (DE)

International Classes:

A61K31/44; A61K31/4402; A61P1/04; A61P1/18; A61P3/14; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; C07D213/74; (IPC1-7): C07D213/74; A61K31/4402; A61P17/00; A61P11/00; A61P9/00

Domestic Patent References:

WO2000048996A2

2000-08-24

Foreign References:

DE10063173A1

2002-06-20

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