Title:
3-DEOXY-2-KETONIC ACID NITROGEN-CONTAINING DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/011554
Kind Code:
A1
Abstract:
The invention relates to a compound represented by general formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable hydrate thereof or pharmaceutically acceptable solvate thereof. The present invention also relates to a pharmaceutical composition comprising the compound, and a preparation method for the compound and a use of the compound.
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Inventors:
LIU XIAOYU (CN)
QIN YONG (CN)
ZHONG WU (CN)
CAO RUIYUAN (CN)
HE HUAN (CN)
ZHENG ZHIBING (CN)
LI SONG (CN)
QIN YONG (CN)
ZHONG WU (CN)
CAO RUIYUAN (CN)
HE HUAN (CN)
ZHENG ZHIBING (CN)
LI SONG (CN)
Application Number:
PCT/CN2020/101906
Publication Date:
January 20, 2022
Filing Date:
July 14, 2020
Export Citation:
Assignee:
UNIV SICHUAN (CN)
ACAD OF MILITARY MEDICAL SCIENCES (CN)
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07H5/06; A61K31/70; A61P31/00; C07H1/00; C12P19/26; C12P19/44
Foreign References:
| US6664399B1 | 2003-12-16 |
Other References:
KIM JIN-HYO, RICARDO RESENDE, TOM WENNEKES, HONG-MING CHEN, NICOLE BANCE, SABRINA BUCHINI, ANDREW G WATTS, PAT PILLING, VICTOR A S: "Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity", SCIENCE, vol. 340, no. 6128, 21 February 2013 (2013-02-21), XP055887096, DOI: 10.1126/science.1232552
PASCOLUTTI MAURO, DIRR LARISSA, GUILLON PATRICE, VAN DEN BERGH ANNELIES, VE THOMAS, THOMSON ROBIN J., VON ITZSTEIN MARK: "Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin–Neuraminidase Using Unsaturated 3- N -Substituted Sialic Acids as Probes", ACS CHEMICAL BIOLOGY, vol. 13, no. 6, 15 June 2018 (2018-06-15), pages 1544 - 1550, XP055887094, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00150
CHENNAIAH ANDE, BHOWMICK SRIJITA, VANKAR YASHWANT D.: "Conversion of glycals into vicinal-1,2-diazides and 1,2-(or 2,1)-azidoacetates using hypervalent iodine reagents and Me 3 SiN 3 . Application in the synthesis of N-glycopeptides, pseudo-trisaccharides and an iminosugar", RSC ADVANCES, vol. 7, no. 66, 1 January 2017 (2017-01-01), pages 41755 - 41762, XP055887092, DOI: 10.1039/C7RA08637G
MENG XIN; YANG MEIBING; LI YANG; LI XIAOBIN; JIA TIANWEI; HE HAOJIE; YU QUN; GUO NA; HE YUN; YU PENG; YANG YANG: "Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents", CHINESE CHEMICAL LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 1, 27 October 2017 (2017-10-27), AMSTERDAM, NL , pages 76 - 80, XP085331276, ISSN: 1001-8417, DOI: 10.1016/j.cclet.2017.10.032
SCIENCE, vol. 340, 2013, pages 71 - 75
ACS CHEM. BIOL., vol. 13, 2018, pages 1544 - 1550
See also references of EP 4183792A4
PASCOLUTTI MAURO, DIRR LARISSA, GUILLON PATRICE, VAN DEN BERGH ANNELIES, VE THOMAS, THOMSON ROBIN J., VON ITZSTEIN MARK: "Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin–Neuraminidase Using Unsaturated 3- N -Substituted Sialic Acids as Probes", ACS CHEMICAL BIOLOGY, vol. 13, no. 6, 15 June 2018 (2018-06-15), pages 1544 - 1550, XP055887094, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00150
CHENNAIAH ANDE, BHOWMICK SRIJITA, VANKAR YASHWANT D.: "Conversion of glycals into vicinal-1,2-diazides and 1,2-(or 2,1)-azidoacetates using hypervalent iodine reagents and Me 3 SiN 3 . Application in the synthesis of N-glycopeptides, pseudo-trisaccharides and an iminosugar", RSC ADVANCES, vol. 7, no. 66, 1 January 2017 (2017-01-01), pages 41755 - 41762, XP055887092, DOI: 10.1039/C7RA08637G
MENG XIN; YANG MEIBING; LI YANG; LI XIAOBIN; JIA TIANWEI; HE HAOJIE; YU QUN; GUO NA; HE YUN; YU PENG; YANG YANG: "Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents", CHINESE CHEMICAL LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 1, 27 October 2017 (2017-10-27), AMSTERDAM, NL , pages 76 - 80, XP085331276, ISSN: 1001-8417, DOI: 10.1016/j.cclet.2017.10.032
SCIENCE, vol. 340, 2013, pages 71 - 75
ACS CHEM. BIOL., vol. 13, 2018, pages 1544 - 1550
See also references of EP 4183792A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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