Title:
3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2023/142214
Kind Code:
A1
Abstract:
A series of 3-hydroxy-5-(isoxazol-5-yl) pyridine formylglycine compounds, a preparation method, a pharmaceutical composition, and the use. A structure of the compounds is shown as formula (I), and the compound derivatives comprise pharmaceutically acceptable salts thereof. The compounds and the pharmaceutical composition thereof have a high inhibition effect on HIF inhibition factors, and the activity can optimally reach the nano-molar concentration level, so that the compounds can be used for preparing a drug for treating fat metabolic diseases. The prepared drug can achieve drug effects in the molecular level, the cell level and the animal level, and has extensive uses. In addition, a synthesis method for the compounds is simple and convenient, and is easy to operate.
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Inventors:
ZHANG XIAOJIN (CN)
WU YUE (CN)
CHEN YAFEN (CN)
LI ZHIHONG (CN)
ZHANG LINJIAN (CN)
LI XIANG (CN)
WU YUE (CN)
CHEN YAFEN (CN)
LI ZHIHONG (CN)
ZHANG LINJIAN (CN)
LI XIANG (CN)
Application Number:
PCT/CN2022/078207
Publication Date:
August 03, 2023
Filing Date:
February 28, 2022
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61K31/41; C07D417/02; A61K31/44; A61P3/00; A61P3/06; C07D413/02
Domestic Patent References:
| WO2014031928A2 | 2014-02-27 | |||
| WO2004018463A2 | 2004-03-04 | |||
| WO2000045799A2 | 2000-08-10 | |||
| WO2002058690A2 | 2002-08-01 | |||
| WO1993019062A1 | 1993-09-30 | |||
| WO2011009484A1 | 2011-01-27 |
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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