Title:
3-SUBSTITUTED-D-HOMO-1,3,5,(10)-ESTRATRIENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/011124
Kind Code:
A1
Abstract:
Because of having excellent estrone sulfatase inhibitory effects, estratriene derivatives represented by general formula (I) are useful in the prevention and treatment of diseases caused by estrogens such as mammary cancer, uterus cancer, ovarian cancer, endometriosis, uterine adenomyosis and mastopathy, wherein one of A and B represents C=O or CH�2? while another represents O or NH; and R represents -SO�2?NR?1�R?2� or -PO(OM)�2? (wherein R?1� and R?2� each independently represent hydrogen or lower alkyl and M represents hydrogen or an alkali metal), provided that when one of A and B is NH, then another is C=O.
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Inventors:
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MIEDA MAMORU (JP)
FUJII TOMOHITO (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MIEDA MAMORU (JP)
FUJII TOMOHITO (JP)
Application Number:
PCT/JP1997/003188
Publication Date:
March 19, 1998
Filing Date:
September 10, 1997
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MIEDA MAMORU (JP)
FUJII TOMOHITO (JP)
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MIEDA MAMORU (JP)
FUJII TOMOHITO (JP)
International Classes:
A61K31/56; C07J73/00; (IPC1-7): C07J73/00
Foreign References:
| JPS5113761A | 1976-02-03 | |||
| JPS49110670A | 1974-10-22 |
Attorney, Agent or Firm:
Odajima, Heikichi (Nippon Jitensha Building 9-15, Akasaka 1-chom, Minato-ku Tokyo 107, JP)
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