3,6-DIAZABICYCLOS[3.1.1]HEPTANE DERIVATIVES WITH ANALGESIC ACTIVITY

Title:

3,6-DIAZABICYCLOS[3.1.1]HEPTANE DERIVATIVES WITH ANALGESIC ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2005/108402

Kind Code:

A1

Abstract:

The invention relates to compounds of general formula (I), wherein R and R₁, different from one another, are: a C₂-C₈straight or branched acyl group; and a group of formula (II), wherein B and R₂ are as defined in the description. The compounds (I) have higher central analgesic activity than morphine and are substantially free from the side effects of morphine or other central analgesics. The invention further relates to a process for the preparation of the compounds (I).

Inventors:

PINNA GERARD AIME (IT)
LORIGA GIOVANNI (IT)
CIGNARELLA GIORGIO (IT)

Application Number:

PCT/EP2005/004994

Publication Date:

November 17, 2005

Filing Date:

May 09, 2005

Export Citation:

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Assignee:

UNIV DEGLI STUDI MILANO (IT)
UNI DEGLI STUDI DI SASSARI (IT)
PINNA GERARD AIME (IT)
LORIGA GIOVANNI (IT)
CIGNARELLA GIORGIO (IT)

International Classes:

A61K31/4995; C07D487/08; (IPC1-7): C07D487/08; A61K31/4995; A61P25/04

Domestic Patent References:

WO2004011468A1	2004-02-05
WO1995023152A1	1995-08-31

Other References:

OCCELLI ET AL.: "Omologhi biciclici della piperazina", IL FARMACO, vol. 33, no. 6, June 1978 (1978-06-01), pages 401 - 420, XP009053808
CIGNARELLA G ET AL: "BICYCLIC HOMOLOGS OF PIPERAZINE. VII. SYNTHESIS AND ANALGESIC ACTIVITY OF 3-ARALKENYL-8-PROPIONYL-3,8-DIAZABICYCLO3.2.1OCTANES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 8, no. 3, February 1990 (1990-02-01), pages 326 - 331, XP000100723, ISSN: 0022-2623

Attorney, Agent or Firm:

Bianchetti, Giuseppe (Via Plinio 63, Milano, IT)

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