3C-LIKE PROTEASE INHIBITOR

WIPO Patent Application WO/2023/226679

A1

The present invention provides a 3C-like protease inhibitor represented by formula (I), or a pharmaceutically acceptable salt or ester thereof, and a stereoisomer or tautomer, a racemate, a nitrogen oxide, a polymorph, a hydrate, a solvate, an isotope marker, a prodrug or a metabolite of the pharmaceutically acceptable salt or ester. The present invention additionally provides a preparation method of the chemical compound, a pharmaceutical composition containing the compound, and the effect of the compound in treating or preventing diseases caused by viral infection.

WO/2002/050067	PHARMACEUTICAL HETEROCYCLIC COMPOUNDS
WO/2019/244066	PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
WO/2004/050024	3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS

ZHANG HONGBO (CN)
YANG QI (CN)
ZHANG WEI (CN)
SUN JING (CN)
SHI LEI (CN)
DING KANG (CN)
WANG HUTING (CN)
XU QINGBO (CN)
HUANG BO (CN)
ZHAO JINCUN (CN)
CHEN XINWEN (CN)
PENG WEI (CN)

PCT/CN2023/091287

November 30, 2023

April 27, 2023

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GUANGZHOU NAT LABORATORY (CN)
BEIJING STONEWISE TECH CO LTD (CN)

C07D401/14; A61K31/53; A61P31/12; A61P31/14; A61P43/00

CN115038696A	2022-09-09
CN115504968A	2022-12-23
CN114507221A	2022-05-17

UNOH, YUTO ET AL.: "Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19", JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, no. 9, 30 March 2022 (2022-03-30), XP093007183, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c00117

LIU , SHEN & ASSOCIATES (CN)

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