Title:
3D PRINTING FORMING METHOD FOR BONE TISSUE GRADIENT STENT HAVING ADJUSTABLE DEGRADATION RATE
Document Type and Number:
WIPO Patent Application WO/2022/170818
Kind Code:
A1
Abstract:
A 3D printing forming method for a bone tissue gradient stent having an adjustable degradation rate, relating to the field of gradient stents. The bone tissue gradient stent at least comprises a first contact surface and a second contact surface which form a closed outer surface of the gradient stent; the interior of the gradient stent is of a porous structure in gradient distribution; the first contact surface is provided with first pores having a diameter smaller than 100 microns, and the second contact surface is provided with second pores having a diameter of hundreds of microns; and adjacent pores among the first pores, the second pores, and internal pores are communicated in a nonlinear transition mode. The gradient stent has a porous structure in gradient distribution, TCP mixed photosensitive resin slurry is used as a material, DLP photocuring is utilized for forming, and resin is removed during sintering. The nonlinear gradient pores inside the stent can adjust the mechanical properties and degradation rate of the stent on the basis of satisfying the surface pore size requirement and the internal pore size requirement of the stent, and the degradation process is free of biotoxicity.
Inventors:
ZHANG BIN (CN)
YIN XIAOHONG (CN)
HONG YIRONG (CN)
YU XIAOWEN (CN)
LI QI (CN)
YIN XIAOHONG (CN)
HONG YIRONG (CN)
YU XIAOWEN (CN)
LI QI (CN)
Application Number:
PCT/CN2021/132984
Publication Date:
August 18, 2022
Filing Date:
January 13, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61F2/28
Foreign References:
| CN112979303A | 2021-06-18 | |||
| CN112190368A | 2021-01-08 | |||
| CN111297518A | 2020-06-19 | |||
| CN110357657A | 2019-10-22 | |||
| CN105769382A | 2016-07-20 | |||
| CN210019802U | 2020-02-07 | |||
| US20180055643A1 | 2018-03-01 |
Other References:
BITTNER SEAN M., SMITH BRANDON T., DIAZ-GOMEZ LUIS, HUDGINS CARRIGAN D., MELCHIORRI ANTHONY J., SCOTT DAVID W., FISHER JOHN P., MI: "Fabrication and mechanical characterization of 3D printed vertical uniform and gradient scaffolds for bone and osteochondral tissue engineering", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 90, 1 May 2019 (2019-05-01), AMSTERDAM, NL, pages 37 - 48, XP055959262, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.03.041
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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