Title:
4-(3-BENZOYLAMINOPHENYL)-6,7-DIMETHOXY-2- METHYLAMINOQUINAZOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/097317
Kind Code:
A1
Abstract:
A compound represented by the formula (I) below, a salt thereof or a hydrate of any of them is capable of effectively suppressing itch of atopic diseases and the like. (I) [In the formula, R represents a hydroxyl group, a C1-6 alkoxy group which may be substituted by a C1-6 alkoxy group, or an amino group which may be substituted by a C1-6 alkyl group.]
Inventors:
MIYAZAKI KAZUKI (JP)
KUSANO KAZUTOMI (JP)
TAKASE YASUTAKA (JP)
ASANO OSAMU (JP)
SHIRATO MANABU (JP)
WAKITA HISASHI (JP)
ISHII NAOTO (JP)
SAEKI TAKAO (JP)
KUSANO KAZUTOMI (JP)
TAKASE YASUTAKA (JP)
ASANO OSAMU (JP)
SHIRATO MANABU (JP)
WAKITA HISASHI (JP)
ISHII NAOTO (JP)
SAEKI TAKAO (JP)
Application Number:
PCT/JP2007/053066
Publication Date:
August 30, 2007
Filing Date:
February 20, 2007
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
MIYAZAKI KAZUKI (JP)
KUSANO KAZUTOMI (JP)
TAKASE YASUTAKA (JP)
ASANO OSAMU (JP)
SHIRATO MANABU (JP)
WAKITA HISASHI (JP)
ISHII NAOTO (JP)
SAEKI TAKAO (JP)
MIYAZAKI KAZUKI (JP)
KUSANO KAZUTOMI (JP)
TAKASE YASUTAKA (JP)
ASANO OSAMU (JP)
SHIRATO MANABU (JP)
WAKITA HISASHI (JP)
ISHII NAOTO (JP)
SAEKI TAKAO (JP)
International Classes:
C07D239/84; A61K31/517; A61P17/00; A61P17/04; A61P37/08
Domestic Patent References:
| WO1999037622A1 | 1999-07-29 | |||
| WO2005082865A1 | 2005-09-09 |
Foreign References:
| JP2001520196A | 2001-10-30 |
Other References:
HANIFIN J.M. ET AL.: "Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 107, no. 1, July 1996 (1996-07-01), pages 51 - 56, XP000915565
SCHMIDT B.M.W. ET AL.: "The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 108, no. 4, October 2001 (2001-10-01), pages 530 - 536, XP008016318
See also references of EP 1992622A4
SCHMIDT B.M.W. ET AL.: "The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 108, no. 4, October 2001 (2001-10-01), pages 530 - 536, XP008016318
See also references of EP 1992622A4
Attorney, Agent or Firm:
HASEGAWA, Yoshiki et al. (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
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