Title:
4-(3H-PYRAZOLO[4,3-F]QUINOLIN-7-YL)-N-(2-(DIMETHYLAMINO)ETHYL)BENZAMIDE- OR HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2023/235837
Kind Code:
A3
Abstract:
N-(2-(dimethylamino)ethyl)benzamide- or hydroxamic acid derivative-comprising compounds for the inhibition of certain kinases for use in certain kinase-mediated disease states. Pharmaceutical compositions, conjugates, and methods for treating those kinase-mediated disease states are also provided.
Inventors:
SINTIM HERMAN (US)
DAYAL NEETU (IN)
HERNANDEZ DELMIS (US)
KEMPEN ALLISON (US)
DAYAL NEETU (IN)
HERNANDEZ DELMIS (US)
KEMPEN ALLISON (US)
Application Number:
PCT/US2023/067822
Publication Date:
February 08, 2024
Filing Date:
June 02, 2023
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION (US)
SINTIM HERMAN (US)
DAYAL NEETU (IN)
HERNANDEZ DELMIS (US)
KEMPEN ALLISON (US)
SINTIM HERMAN (US)
DAYAL NEETU (IN)
HERNANDEZ DELMIS (US)
KEMPEN ALLISON (US)
International Classes:
C07D221/12; C07D401/14; C07D471/04; C07D471/14; C07D491/147; C07D519/00
Foreign References:
| US20210371420A1 | 2021-12-02 | |||
| US20200010471A1 | 2020-01-09 |
Other References:
DAYAL NEETU, OPOKU-TEMENG CLEMENT, HERNANDEZ DELMIS E, SOORESHJANI MOLOUD AFLAKI, CARTER-COOPER BRANDON A, LAPIDUS RENA G, SINTIM : "Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines", FUTURE MEDICINAL CHEMISTRY, FUTURE SCIENCE LTD., GB, vol. 10, no. 7, 1 April 2018 (2018-04-01), GB , pages 823 - 835, XP093138467, ISSN: 1756-8919, DOI: 10.4155/fmc-2017-0298
DATABASE PubChem NCBI; ANONYMOUS : "N-[2-(dimethylamino)ethyl]-4-(6,7,12-triazapentacyclo[13.2.1.02,14.03,11.04,8]octadeca-2(14),3(11),4(8),5,9,12-hexaen-13-yl)benzamide | C26H27N5O |", XP093138471
KEMPEN ALLISON L., BRAUER NICKOLAS R., SINTIM HERMAN O.: "Dual FLT3/haspin kinase inhibitor based on 3 H -pyrazolo[4,3- f ]quinoline scaffold with activities against acute myeloid leukemia", RSC MEDICINAL CHEMISTRY, vol. 14, no. 9, 19 September 2023 (2023-09-19), pages 1743 - 1754, XP093138474, ISSN: 2632-8682, DOI: 10.1039/D3MD00192J
KEMPEN ALLISON L., BRAUER NICKOLAS R., SINTIM HERMAN O.: "Dual FLT3/haspin kinase inhibitor based on 3 H -pyrazolo[4,3- f ]quinoline scaffold with activities against acute myeloid leukemia", RSC MEDICINAL CHEMISTRY, vol. 14, no. 9, 19 September 2023 (2023-09-19), pages 1743 - 1754, XP093138474, ISSN: 2632-8682, DOI: 10.1039/D3MD00192J
DATABASE PubChem NCBI; ANONYMOUS : "N-[2-(dimethylamino)ethyl]-4-(6,7,12-triazapentacyclo[13.2.1.02,14.03,11.04,8]octadeca-2(14),3(11),4(8),5,9,12-hexaen-13-yl)benzamide | C26H27N5O |", XP093138471
KEMPEN ALLISON L., BRAUER NICKOLAS R., SINTIM HERMAN O.: "Dual FLT3/haspin kinase inhibitor based on 3 H -pyrazolo[4,3- f ]quinoline scaffold with activities against acute myeloid leukemia", RSC MEDICINAL CHEMISTRY, vol. 14, no. 9, 19 September 2023 (2023-09-19), pages 1743 - 1754, XP093138474, ISSN: 2632-8682, DOI: 10.1039/D3MD00192J
KEMPEN ALLISON L., BRAUER NICKOLAS R., SINTIM HERMAN O.: "Dual FLT3/haspin kinase inhibitor based on 3 H -pyrazolo[4,3- f ]quinoline scaffold with activities against acute myeloid leukemia", RSC MEDICINAL CHEMISTRY, vol. 14, no. 9, 19 September 2023 (2023-09-19), pages 1743 - 1754, XP093138474, ISSN: 2632-8682, DOI: 10.1039/D3MD00192J
Attorney, Agent or Firm:
DEAN, Natalie, J. (US)
Download PDF: