Title:
4-AZA-STEROIDS
Document Type and Number:
WIPO Patent Application WO1998050419
Kind Code:
A3
Abstract:
4-Aza-steroid compounds are provided, which have functional groups at one or more of positions 7, 11 and 15, such as hydroxyl or hydroxyl derivative groups. The compounds are active against 5-alpha-reductase giving indications of utility in combating prostate cancer. The compounds can be prepared by chemo-enzymatic synthesis from easily available 4-aza-steroids.
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Inventors:
PAMIDI CHENCHAIAH CHINNA (CA)
JIA QI (CA)
JIA QI (CA)
Application Number:
PCT/CA1998/000438
Publication Date:
February 04, 1999
Filing Date:
May 06, 1998
Export Citation:
Assignee:
NOVOPHARM LTD (CA)
PAMIDI CHENCHAIAH CHINNA (CA)
JIA QI (CA)
PAMIDI CHENCHAIAH CHINNA (CA)
JIA QI (CA)
International Classes:
A61P35/00; A61K31/58; A61P43/00; C07J71/00; C07J73/00; (IPC1-7): C07J73/00
Domestic Patent References:
| WO1995013077A1 | 1995-05-18 | |||
| WO1995013815A1 | 1995-05-26 | |||
| WO1995012398A1 | 1995-05-11 |
Foreign References:
| EP0572166A1 | 1993-12-01 | |||
| EP0572165A1 | 1993-12-01 |
Other References:
RASMUSSON G H ET AL: "AZASTEROIDS AS INHIBITORS OF RAT PROSTATIC 5ALPHA-REDUCTASE", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 12, December 1984 (1984-12-01), pages 1690 - 1701, XP002043194
RASMUSSON G H ET AL: "AZASTEROIDS: STRUCTURE-ACTIVITY RELATIONSHIPS FOR INHIBITION OF 5ALPHA-REDUCTASE AND OF ANDROGEN RECEPTOR BINDING", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 11, 1 November 1986 (1986-11-01), pages 2298 - 2315, XP000568779
ISHIBASHI K ET AL: "Synthesis and testosterone 5alpha-reductase inhibitory activity of 11 -substituted 4-aza-5alpha-androstane compounds", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA, vol. 31, no. 9, 1996, pages 675-681, XP004040245
RASMUSSON G H ET AL: "AZASTEROIDS: STRUCTURE-ACTIVITY RELATIONSHIPS FOR INHIBITION OF 5ALPHA-REDUCTASE AND OF ANDROGEN RECEPTOR BINDING", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 11, 1 November 1986 (1986-11-01), pages 2298 - 2315, XP000568779
ISHIBASHI K ET AL: "Synthesis and testosterone 5alpha-reductase inhibitory activity of 11 -substituted 4-aza-5alpha-androstane compounds", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA, vol. 31, no. 9, 1996, pages 675-681, XP004040245
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