Title:
4-HYDROXYPIPERIDINE DERIVATIVES HAVING ANTIARRHYTHMIC EFFECT
Document Type and Number:
WIPO Patent Application WO/2000/061557
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) or salts thereof and medicinal compositions containing these compounds as the active ingredient: wherein A represents, for example, phenyl substituted by R?1¿ and R?2¿ or unsubstituted thienyl (wherein R?1¿ and R?2¿ independently represent each hydrogen, halogeno, lower alkoxycarbonyl, etc.); R?3¿ represents, for example, hydrogen; R?4¿ represents, for example, lower alkyl; R?5¿ represents, for example, lower alkoxy; R?6¿ represents, for example, hydrogen; R?7¿ and R?8¿ represent, for example, each hydrogen; X represents, for example, a single bond; Y represents, for example, methylene or benzylidene substituted by R?1¿; and Z represents, for example, methylene. These compounds are useful in preventing and/or treating arrhythmia and preventives for sudden death as drugs which neither inhibit transient sodium current in cardiac muscles nor show any arrhythmia-inducing effect.
Inventors:
YAMAMOTO ICHIRO (JP)
ITOH MANABU (JP)
YAMASAKI FUMIAKI (JP)
MIYAZAKI YUTAKA (JP)
OGAWA SHINICHI (JP)
ITOH MANABU (JP)
YAMASAKI FUMIAKI (JP)
MIYAZAKI YUTAKA (JP)
OGAWA SHINICHI (JP)
Application Number:
PCT/JP2000/002331
Publication Date:
October 19, 2000
Filing Date:
April 10, 2000
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
YAMAMOTO ICHIRO (JP)
ITOH MANABU (JP)
YAMASAKI FUMIAKI (JP)
MIYAZAKI YUTAKA (JP)
OGAWA SHINICHI (JP)
YAMAMOTO ICHIRO (JP)
ITOH MANABU (JP)
YAMASAKI FUMIAKI (JP)
MIYAZAKI YUTAKA (JP)
OGAWA SHINICHI (JP)
International Classes:
A61P9/06; A61P25/04; A61P29/02; C07D211/48; C07D405/06; C07D407/06; C07D409/06; (IPC1-7): C07D211/48; C07D405/06; C07D409/06; A61K31/445; A61K31/4525; A61K31/4535; A61P9/06
Foreign References:
| EP0867183A1 | 1998-09-30 | |||
| US4248877A | 1981-02-03 |
Other References:
HUEGI B.S. ET AL.: "Synthesis and pharmacological studies of 4,4-disubstituted piperidines: A new class of compounds with potent analgetic properties", J. MED. CHEM.,, vol. 26, no. 1, 1983, pages 42 - 50, XP002929094
See also references of EP 1182192A4
See also references of EP 1182192A4
Attorney, Agent or Firm:
Hanabusa, Tsuneo (Ochanomizu Square B 6 Kandasurugadai 1-chome Chiyoda-ku, Tokyo, JP)
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