Title:
4-OXO-4,5-DIHYDRO-FURAN-2-CARBOXYLIC AND ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
Document Type and Number:
WIPO Patent Application WO2005051937
Kind Code:
A8
Abstract:
The present invention relates to certain 4-oxo-4,5-dihydro-furan-2-carboxylic acid and ester derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X, and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of a-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, and the like.
Inventors:
JUNG JAE-KYU (US)
SEMPLE GRAEME (US)
JOHNSON BENJAMIN R (US)
SEMPLE GRAEME (US)
JOHNSON BENJAMIN R (US)
Application Number:
PCT/US2004/038920
Publication Date:
August 31, 2006
Filing Date:
November 18, 2004
Export Citation:
Assignee:
ARENA PHARM INC (US)
JUNG JAE-KYU (US)
SEMPLE GRAEME (US)
JOHNSON BENJAMIN R (US)
JUNG JAE-KYU (US)
SEMPLE GRAEME (US)
JOHNSON BENJAMIN R (US)
International Classes:
C07D307/68; C07D409/04; C07D409/10
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