Title:
4-OXOQUINOLIZINE ANTIMICROBIALS HAVING 2-PYRIDONE SKELETONS AS THE PARTIAL STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2001/029035
Kind Code:
A1
Abstract:
4-Oxoquinolizine antimicrobials having 2-pyridone skeletons as the partial structure and exhibiting potent antimicrobial activities against gram-positive or -negative bacteria or anaerobic bacteria, which are compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R¿1? is hydrogen or a carboxyl-protecting group; R¿2? is hydrogen, halogeno, lower alkyl, lower alkoxy, or hydroxyl; R¿3? is hydrogen, halogeno, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, hydroxyl, or amino; R¿4? is hydrogen, an amino-protecting group, alkyl, or cycloalkyl; and R¿5? is hydrogen, halogeno, alkyl, alkenyl, cycloalkyl, aryl, alkoxy, alkylthio, hydroxyl, imino, or amino.
Inventors:
FUKUMOTO RYOICHI (JP)
KUSAKABE HIROYUKI (JP)
CHU CHONG (JP)
KIMURA HIROAKI (JP)
YANAGIHARA SATOSHI (JP)
KATO MASATOSHI (JP)
HIROSAWA CHISATO (JP)
ISHIDUKA SEIJI (JP)
SHIZUME FUSAE (JP)
KUSAKABE HIROYUKI (JP)
CHU CHONG (JP)
KIMURA HIROAKI (JP)
YANAGIHARA SATOSHI (JP)
KATO MASATOSHI (JP)
HIROSAWA CHISATO (JP)
ISHIDUKA SEIJI (JP)
SHIZUME FUSAE (JP)
Application Number:
PCT/JP2000/007256
Publication Date:
April 26, 2001
Filing Date:
October 19, 2000
Export Citation:
Assignee:
SATO PHARMA (JP)
FUKUMOTO RYOICHI (JP)
KUSAKABE HIROYUKI (JP)
CHU CHONG (JP)
KIMURA HIROAKI (JP)
YANAGIHARA SATOSHI (JP)
KATO MASATOSHI (JP)
HIROSAWA CHISATO (JP)
ISHIDUKA SEIJI (JP)
SHIZUME FUSAE (JP)
FUKUMOTO RYOICHI (JP)
KUSAKABE HIROYUKI (JP)
CHU CHONG (JP)
KIMURA HIROAKI (JP)
YANAGIHARA SATOSHI (JP)
KATO MASATOSHI (JP)
HIROSAWA CHISATO (JP)
ISHIDUKA SEIJI (JP)
SHIZUME FUSAE (JP)
International Classes:
A61K31/4375; A61P31/04; C07D455/02; (IPC1-7): C07D455/02; A61K31/4375; A61P31/04
Domestic Patent References:
| WO1995010519A1 | 1995-04-20 |
Other References:
MA ZHENKUN ET AL.: "Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: Consequences of structural modification at the C-8 position", J. MED. CHEM., vol. 42, no. 20, 1999, pages 4202 - 4213, XP002936065
Attorney, Agent or Firm:
Nakamura, Minoru (Shin-Tokyo Bldg. 3-1 Marunouchi 3-Chome Chiyoda-Ku, Tokyo, JP)
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