4-(P-TRIFLUOROMETHYLBENZYL)-3-FLORO-1,2,4 TRIPHENYLAMINE DERIVATIVE, PHARMACEUTICAL COMPOSITION OF SAME, AND USES THEREOF

WIPO Patent Application WO/2020/001298

A1

Provided in the present invention are a 4-(p-trifluoromethylbenzyl)-3-floro-1,2,4 triphenylamine derivative, a pharmaceutical composition of same, and uses thereof. The chemical formula of the derivative is as represented by formula I, where R is a C1-C6 alkyl, a cycloalkyl, a heteroatom-containing cycloalkyl, an aromatic ring, or a heteroatom-containing aromatic ring, the heteroatom is selected from N or O; n is 0, 1, 2, or 3; and the pharmaceutical composition has any of the 4-(p-trifluoromethylbenzyl)-3-floro-1,2,4 triphenylamine derivatives described above as the active ingredient and, at the same time, contains one or more pharmaceutically acceptable carrier. The derivative and the pharmaceutical composition are provided with a significantly activated KCNQ channel current; therefore, the derivative is applicable in preparing a KCNQ potassium channel opener, also applicable as an active ingredient of an antiepileptic medicinal preparation, and as an active ingredient of an anxiety relieving medicinal preparation and of a neuropathic pain relieving medicinal preparation.

ZHANG HAILIN (CN)
QI JINLONG (CN)
JIA QINGZHONG (CN)
DU XIAONA (CN)
HAO HAN (CN)

PCT/CN2019/091365

January 02, 2020

June 14, 2019

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UNIV HEBEI MEDICAL (CN)

A61K31/167; C07C231/02; A61K31/341; A61K31/4465; A61P25/02; A61P25/08; A61P25/22; A61P29/00; C07C233/43; C07C233/44; C07D211/34; C07D295/15; C07D307/54

WO2016077724A1

2016-05-19

CN108707087A	2018-10-26
CN1761464A	2006-04-19
CN101056845A	2007-10-17

SHIJIAZHUANG GUOYU PATENT TRADEMARK AGENCY et al. (CN)

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