Title:
4-SUBSTITUTED PYRIDAZINONE COMPOUND AND P2X7 RECEPTOR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2010/126104
Kind Code:
A1
Abstract:
Disclosed is a novel pyridazinone compound having an activity of inhibiting P2X7 receptor that is a kind of purine receptor, which is useful in preventing, treating or ameliorating diseases relating to inflammation or immunity.
Specifically disclosed is a novel pyridazinone compound represented by formula (I) [wherein R1, R2, Q, X, Y and Z are each as defined in the description], a tautomer of said compound, a prodrug thereof, a pharmaceutically acceptable salt thereof or a solvate of the same.
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Inventors:
IO MEGUMI (JP)
SHINTANI YUSUKE (JP)
SHIGETA YUKIHIRO (JP)
KAMON JUNJI (JP)
SHINTANI YUSUKE (JP)
SHIGETA YUKIHIRO (JP)
KAMON JUNJI (JP)
Application Number:
PCT/JP2010/057618
Publication Date:
November 04, 2010
Filing Date:
April 28, 2010
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
IO MEGUMI (JP)
SHINTANI YUSUKE (JP)
SHIGETA YUKIHIRO (JP)
KAMON JUNJI (JP)
IO MEGUMI (JP)
SHINTANI YUSUKE (JP)
SHIGETA YUKIHIRO (JP)
KAMON JUNJI (JP)
International Classes:
C07D237/20; A61K31/50; A61K31/501; A61K31/5377; A61P1/02; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P33/06; A61P35/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| WO2008080056A2 | 2008-07-03 | |||
| WO2008016239A1 | 2008-02-07 |
Foreign References:
| JPS5291883A | 1977-08-02 | |||
| JPH0995485A | 1997-04-08 | |||
| US5723411A | 1998-03-03 | |||
| JPS625967A | 1987-01-12 | |||
| JPH08198855A | 1996-08-06 | |||
| JP2003512292A | 2003-04-02 |
Other References:
M. TAKAYA ET AL.: "A New Nonsteroidal Analgesic-Antiinflammatory Agent. Synthesis and Activity of 4-Ethoxy-2-methyl-5- morpholino-3(2H)-pyridazinone and Related Compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 1, 1979, pages 53 - 58, XP002485738, DOI: doi:10.1021/jm00187a013
VACLAV KONECNY ET AL.: "Synthesis of Novel 4- Amino-5-(disubstituted amino)-2-phenyl-2H- pyridazin-3-ones", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 62, no. 5, 1997, pages 800 - 808
TORIZO TAKAHASHI ET AL.: "Studies on Pyridazone Derivatives. III.: Synthesis of 2-Phenyl-3(2H)-pyridazinone Derivatives", YAKUGAKU ZASSHI, vol. 88, no. 6, 1968, pages 784 - 786
P. MATYUS ET AL.: "Novel Pyridazino[4,5-b] [1,5]oxazepines and -thiazepines as 5-HT1A Receptor Ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 22, 1997, pages 2857 - 2862, XP004136544, DOI: doi:10.1016/S0960-894X(97)10089-0
NADYA KAVAL ET AL.: "Convenient and rapid microwave-assisted synthesis of pyrido-fused ring systems applying the tert-amino effect", GREEN CHEMISTRY, vol. 6, no. 3, 2004, pages 125 - 127
THOMAS M. STEVENSON ET AL.: "Application of Cross-Coupling and Metalation Chemistry of 3(2H)-Pyridazinones to Fungicide and Herbicide Discovery", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 42, no. 3, 2005, pages 427 - 435, XP002442886, DOI: doi:10.1002/jhet.5570420310
MASAHIRO TAKAYA ET AL.: "Studies on Pyridazinone Derivatives. IX. Sythesis and Hemostatic Activity of 2,4,5-Trisubstituted- 3(2H)-pyridazinones", YAKUGAKU ZASSHI, vol. 98, no. 11, 1978, pages 1530 - 1535, XP002086878
BEATA DAJKA-HALASZ ET AL.: "Study of tert- amino effect: the role of substituents in isomerization of 5-amino-4-vinyl-3(2H)- pyridazinones", ARKIVOC, 2008, pages 102 - 126
VACLAV KONECNY ET AL.: "Synthesis of Novel 4- Amino-5-(disubstituted amino)-2-phenyl-2H- pyridazin-3-ones", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 62, no. 5, 1997, pages 800 - 808
TORIZO TAKAHASHI ET AL.: "Studies on Pyridazone Derivatives. III.: Synthesis of 2-Phenyl-3(2H)-pyridazinone Derivatives", YAKUGAKU ZASSHI, vol. 88, no. 6, 1968, pages 784 - 786
P. MATYUS ET AL.: "Novel Pyridazino[4,5-b] [1,5]oxazepines and -thiazepines as 5-HT1A Receptor Ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 22, 1997, pages 2857 - 2862, XP004136544, DOI: doi:10.1016/S0960-894X(97)10089-0
NADYA KAVAL ET AL.: "Convenient and rapid microwave-assisted synthesis of pyrido-fused ring systems applying the tert-amino effect", GREEN CHEMISTRY, vol. 6, no. 3, 2004, pages 125 - 127
THOMAS M. STEVENSON ET AL.: "Application of Cross-Coupling and Metalation Chemistry of 3(2H)-Pyridazinones to Fungicide and Herbicide Discovery", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 42, no. 3, 2005, pages 427 - 435, XP002442886, DOI: doi:10.1002/jhet.5570420310
MASAHIRO TAKAYA ET AL.: "Studies on Pyridazinone Derivatives. IX. Sythesis and Hemostatic Activity of 2,4,5-Trisubstituted- 3(2H)-pyridazinones", YAKUGAKU ZASSHI, vol. 98, no. 11, 1978, pages 1530 - 1535, XP002086878
BEATA DAJKA-HALASZ ET AL.: "Study of tert- amino effect: the role of substituents in isomerization of 5-amino-4-vinyl-3(2H)- pyridazinones", ARKIVOC, 2008, pages 102 - 126
Attorney, Agent or Firm:
SENMYO, Kenji et al. (JP)
Spring name Kenji (JP)
Spring name Kenji (JP)
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