Title:
4,6-HEXADECADIENE-2,4-DICARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/002967
Kind Code:
A1
Abstract:
Provided is a 4,6-hexadecadiene-2,4-dicarboxylic acid derivative or pharmaceutically acceptable salt thereof or the like, having anti-tumour activity and represented by general formula (I): [in the formula, R1 represents a hydroxy, –OR3 (in the formula, R3 represents a lower alkyl that may have a substituent, or an aliphatic heterocyclic group that may have a substituent) or –NR4R5 (in the formula, R4 and R5 are the same or different, and each represent a hydrogen atom, or a lower alkyl that may have a substituent), and R2 represents a hydroxy or –OR6 (in the formula, R6 represents a lower alkyl that may have a substituent or an aralkyl that may have a substituent)].
Inventors:
YAMAGUCHI SHIMPEI (JP)
UOCHI YUMIKO (JP)
AGATSUMA TSUTOMU (JP)
IWAMOTO SUSUMU (JP)
ONODERA HIDEYUKI (JP)
UOCHI YUMIKO (JP)
AGATSUMA TSUTOMU (JP)
IWAMOTO SUSUMU (JP)
ONODERA HIDEYUKI (JP)
Application Number:
PCT/JP2013/067297
Publication Date:
January 03, 2014
Filing Date:
June 25, 2013
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C12N1/14; A61K31/201; A61K31/231; A61K31/365; A61K31/661; A61K36/06; A61P35/00; C07C69/602; C07C69/675; C07C233/27; C07D307/33
Domestic Patent References:
| WO1998000121A1 | 1998-01-08 |
Foreign References:
| JP2009167219A | 2009-07-30 | |||
| JP2008266295A | 2008-11-06 | |||
| JP2009541322A | 2009-11-26 | |||
| JPS5081863A | 1975-07-02 | |||
| US3849458A | 1974-11-19 | |||
| JPH0519536B2 | 1993-03-17 | |||
| JPS61277648A | 1986-12-08 | |||
| JPS61275241A | 1986-12-05 | |||
| JPS63198638A | 1988-08-17 |
Other References:
YU, Z. ET AL.: "Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus, Scopulariopsis brevicaulis", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 6, 2008, pages 1052 - 1054, XP002514970
TETRAHEDRON LETTERS, vol. 14, no. 23, 1973, pages 2333 - 2334
TETRAHEDRON LETTERS, vol. 18, no. 47, 1977, pages 4083 - 4084
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
CRAMER, VADUZ; J. A. VON ARX: "The Genera of Fungi Sporulating in Pure Culture", 1974
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH VERLAGSGESELLSCHAFT MBH
J. AM. CHEM. SOC., vol. 124, no. 10, 2002, pages 2092
LIPIDS, vol. 9, no. 11, 1974, pages 913
"Iyakuhin no Kaihatsu", vol. 7, 1990, HIROKAWA SHOTEN, pages: 163
See also references of EP 2865747A4
TETRAHEDRON LETTERS, vol. 14, no. 23, 1973, pages 2333 - 2334
TETRAHEDRON LETTERS, vol. 18, no. 47, 1977, pages 4083 - 4084
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
CRAMER, VADUZ; J. A. VON ARX: "The Genera of Fungi Sporulating in Pure Culture", 1974
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH VERLAGSGESELLSCHAFT MBH
J. AM. CHEM. SOC., vol. 124, no. 10, 2002, pages 2092
LIPIDS, vol. 9, no. 11, 1974, pages 913
"Iyakuhin no Kaihatsu", vol. 7, 1990, HIROKAWA SHOTEN, pages: 163
See also references of EP 2865747A4
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