Title:
4,7-DIAMINO-PYRIDO[2,3-D] PYRIMIDINE DERIVATIVE FOR USE AS JAK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/088289
Kind Code:
A1
Abstract:
The present invention relates to a novel compound being a JAK inhibitor. The compound is a compound of formula (I), its pharmaceutically acceptable salt, prodrug, metabolite, isotope derivative, and solvate, or a pharmaceutical composition containing the compound, and can be employed to prevent or treat a Janus kinase(JAK)-related disease or symptom in a human patient or a mammal patient. The present invention also relates to applications of the compound in which the compound is used as a Janus kinase (JAK) inhibitor in medical experiments, pharmaceutical experiments, biological experiments, physiological experiments, biochemical experiments, and the like.
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Inventors:
CHEN YILIN (CN)
PENG HONG (CN)
TAO LIN (CN)
ZHAO YAN (CN)
ZHANG XIAOLI (CN)
ZHAO YINYING (CN)
ZOU YANG (CN)
LI YONGHUA (CN)
WANG XIAOXIA (CN)
PENG HONG (CN)
TAO LIN (CN)
ZHAO YAN (CN)
ZHANG XIAOLI (CN)
ZHAO YINYING (CN)
ZOU YANG (CN)
LI YONGHUA (CN)
WANG XIAOXIA (CN)
Application Number:
PCT/CN2016/070339
Publication Date:
June 01, 2017
Filing Date:
January 07, 2016
Export Citation:
Assignee:
HELIOEAST PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61K31/52; A61K31/5377; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; C07D519/00
Domestic Patent References:
| WO2012143320A1 | 2012-10-26 | |||
| WO2014145576A2 | 2014-09-18 |
Foreign References:
| CN1409712A | 2003-04-09 | |||
| CN1305480A | 2001-07-25 |
Other References:
LIAO, GAOHONG: "Research and Development of Small Molecule Janus Kinase Inhibitors", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 38, no. 2, 28 February 2014 (2014-02-28), pages 112 - 119
Attorney, Agent or Firm:
BEIJING EAST IP LTD. (CN)
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