Title:
5-MEMBERED RING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2000/011021
Kind Code:
A1
Abstract:
5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR¿1?, Y is =O and Z is H, and when it is a cyclopentane ring, X is =O, Y is OR¿2? and Z is OR¿3?, (wherein R¿1? is R¿4? or -(CO)-R¿5?; R¿2? is H,-R¿6? or -(CO)-R¿7?; and R¿3? is H, R¿8? or (CO)-R¿9? (wherein R¿4?, R¿5?, R¿6?, R¿7?, R¿8? and R¿9? are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R¿5?, R¿7? and R¿9? may be each H), provided that the case where R¿2?=R¿3?=H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.
Inventors:
KOBAYASHI EIJI (JP)
OHNOGI HIROMU (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
SAGAWA HIROAKI (JP)
KATO IKUNOSHIN (JP)
OHNOGI HIROMU (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
SAGAWA HIROAKI (JP)
KATO IKUNOSHIN (JP)
Application Number:
PCT/JP1999/004324
Publication Date:
March 02, 2000
Filing Date:
August 10, 1999
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
KOBAYASHI EIJI (JP)
OHNOGI HIROMU (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
SAGAWA HIROAKI (JP)
KATO IKUNOSHIN (JP)
KOBAYASHI EIJI (JP)
OHNOGI HIROMU (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
SAGAWA HIROAKI (JP)
KATO IKUNOSHIN (JP)
International Classes:
C07K5/02; C07K5/027; A61K38/00; (IPC1-7): C07K5/027; C07K1/02; C07C323/60; C07C319/18; A61K31/195
Domestic Patent References:
| WO1998039291A1 | 1998-09-11 |
Foreign References:
| JPH05310685A | 1993-11-22 | |||
| JPH1045618A | 1998-02-17 |
Other References:
MIYAGUCHI SHINGO ET AL.: "Relationship Between alpha-mannosidase and natural killer activity and glycopeptides of peripheral blood mononuclear cells in patients with liver cirrhosis or hepatocellular carcinoma", KEIO IGAKU,, vol. 69, no. 2, 1992, pages 335 - 346, XP002925534
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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