Title:
5-O-DESOSAMINYLERYTHRONOLIDE A DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1993/021200
Kind Code:
A1
Abstract:
Object: to provide a novel macrolide antibiotic having a potent antibacterial activity. Constitution: a tricyclic carbamate derivative of a 3-oxo-6-methoxy-substituted 5-O-desosaminylerythronolide A derivative represented by general formula (I), and a pharmaceutically acceptable acid addition salt thereof. In formula (I), -A$(1,3)$ represents -N(R3)- (wherein R3 represents hydrogen or C1-C3 alkyl) or -N=; and R1 and R2 represent each C1-C3 alkyl. An intermediate, represented by general formula (II), useful for producing the 3-oxo-substituted 5-O-desosaminylerythronolide A derivative, wherein R4 represents acetyl or propionyl.
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Inventors:
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)
Application Number:
PCT/JP1993/000517
Publication Date:
October 28, 1993
Filing Date:
April 21, 1993
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)
International Classes:
A61K31/395; C07D491/00; C07H17/00; C07H17/08; (IPC1-7): C07H17/00; C07H17/08
Domestic Patent References:
WO1992009614A1 | 1992-06-11 |
Foreign References:
EP0487411A1 | 1992-05-27 | |||
JPS62292795A | 1987-12-19 |
Other References:
See also references of EP 0638585A4
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