5-PYRIDINE-1H-INDAZOLE COMPOUND FOR TARGETED INHIBITION OF CLK2 AND USE OF COMPOUND

Title:

5-PYRIDINE-1H-INDAZOLE COMPOUND FOR TARGETED INHIBITION OF CLK2 AND USE OF COMPOUND

Document Type and Number:

WIPO Patent Application WO/2024/051720

Kind Code:

A1

Abstract:

Disclosed in the present invention are a 5-pyridine-1H-indazole compound for targeted inhibition of CLK2 and a use of the compound. The compound of the present invention is a compound represented by formula (I), formula (II) or formula (III), or a pharmaceutically acceptable salt, a prodrug, a hydrate, or a solvate thereof. The compound of the present invention has remarkable CLK2 inhibitory activity, has good selectivity on CLK family members, has remarkable DYRK1A inhibitory activity, and shows good anti-osteoarthritis activity both in vitro and in vivo.

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Inventors:

LI ZHIYU (CN)
BIAN JINLEI (CN)
SONG JIAXING (CN)
QIU ZHIXIA (CN)
HU TIANXING (CN)
LIU MAI (CN)
QIN ZHEN (CN)

Application Number:

PCT/CN2023/117144

Publication Date:

March 14, 2024

Filing Date:

September 06, 2023

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Assignee:

UNIV CHINA PHARMA (CN)

International Classes:

C07D401/14; A61K31/4439; A61K31/444; A61K31/4709; A61K31/4725; A61K31/506; A61P19/02; C07D401/04; C07D409/14; C07D417/14

Domestic Patent References:

WO2005085227A1	2005-09-15
WO2020006115A1	2020-01-02
WO2020150552A2	2020-07-23

Foreign References:

CN115304583A	2022-11-08
CN104837842A	2015-08-12
CN110156785A	2019-08-23

Other References:

K. W. WOODS ET AL.: "Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 20, 14 July 2006 (2006-07-14), AMSTERDAM, NL, pages 6832 - 6846, XP002506916, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2006.06.047

Attorney, Agent or Firm:

NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)

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