5,8-DISUBSTITUTED-1,6-NAPHTHYRIDINE-7-CARBONYL AMIDE COMPOUNDS, THEIR PREPARATION METHODS, COMPOSITIONS AND USE

Title:

5,8-DISUBSTITUTED-1,6-NAPHTHYRIDINE-7-CARBONYL AMIDE COMPOUNDS, THEIR PREPARATION METHODS, COMPOSITIONS AND USE

Document Type and Number:

WIPO Patent Application WO/2010/037249

Kind Code:

A1

Abstract:

The invention discloses 5,8-disubstituted-1,6-naphthyridine-7-carbonyl amide compounds, their preparation methods, their use and the pharmaceutical compositions comprising the compounds. More specifically, the invention discloses 5,8-disubstituted-1,6-naphthyridine-7-carbonyl amide compounds with the following structure represented by formula I, their preparation methods and their use. The suppressing tests of several kinds of tumor cell lines (human breast cancer cell MDA-MB-435, p53 absent poorly-differentiated colonic adenocarcinoma cell Hct116p53-/-, p53 enriched poorly-differentiated colonic adenocarcinoma cell Hct116p53+/+, human breast cancer cell Mcf-7, NIH189, human breast cancer cell SKBr-3, prostate cancer cell LnCap, LnHer, human colon cancer cell HT29, human ovarian cancer cell HEY) show that the compounds possess good inhibiting activities and could be used in treating the diseases induced by tumor cell malignant proliferation. The invention also discloses the pharmaceutical compositions comprising the above-said compounds.

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Inventors:

LONG YAQIU (CN)
ZENG LIFAN (CN)
WANG YONG (CN)
DING JIAN (CN)

Application Number:

PCT/CN2009/000970

Publication Date:

April 08, 2010

Filing Date:

August 24, 2009

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA (CN)
LONG YAQIU (CN)
ZENG LIFAN (CN)
WANG YONG (CN)
DING JIAN (CN)

International Classes:

C07D471/04; A61K31/4375; A61K31/496; A61K31/535; A61P35/00

Domestic Patent References:

WO1999009030A1

1999-02-25

Foreign References:

CN1863774A	2006-11-15
CN101155588A	2008-04-02

Attorney, Agent or Firm:

KINGSOUND & PARTNERS (Block BKingsound International Center,116 Zizhuyuan Road,Haidian District, Beijing 7, CN)

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