Title:
5HT2A RECEPTOR ANTAGONIST AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/147909
Kind Code:
A1
Abstract:
Provided is a compound of a structure of formula (I) having a central nervous system disease treatment effect, which has the activity of a 5-HT2A receptor antagonist or an inverse agonist, has high 5-HT2A receptor selectivity, low cardiotoxicity, and good metabolic stability, and can be applied to treat some mental diseases (such as depression, anxiety disorders, psychiatric disorders, schizophrenia, insomnia, and autism) and central nervous system degenerative disorder (such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and dementia with Lewy bodies)-related or complicated mental disorders.
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Inventors:
XING HONGTAO (CN)
Application Number:
PCT/CN2021/072899
Publication Date:
July 29, 2021
Filing Date:
January 20, 2021
Export Citation:
Assignee:
HANG YUN MEDICAL TECH CO LTD (CN)
International Classes:
A61K31/397; C07D405/12; A61K31/4025; A61K31/453; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28
Domestic Patent References:
| WO2019040107A1 | 2019-02-28 | |||
| WO2009039460A2 | 2009-03-26 | |||
| WO2010111353A1 | 2010-09-30 |
Foreign References:
| US20080280886A1 | 2008-11-13 | |||
| CN101035759A | 2007-09-12 |
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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